免疫检查点抑制剂相关的胰腺炎:已知和未知
Chunyan Jiang1, Wen Tang1, Xu Yang2
1Department of Internal Medicine and Geriatrics, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Open medicine (Warsaw, Poland)
|June 5, 2023
概括
免疫检查点抑制剂 (ICI) 治疗很少会导致胰腺炎. 这一案例突出了一个患有口腔癌的患者,他在辛蒂利马布治疗后出现了严重的胰腺炎,并成功地用类固醇和胰岛素进行了治疗.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 免疫检查点抑制剂 (ICI),如sintilimab (一种编程细胞死亡蛋白1抑制剂),越来越多地用于癌症治疗.
- 与ICI相关的不良事件可能是多样化的,有时是严重的,需要迅速识别和管理.
研究的目的:
- 报告免疫检查点抑制剂 (ICI) 相关的胰腺炎病例.
- 描述这种罕见并发症的临床表现,诊断和管理.
- 突出需要进一步研究ICI相关的胰腺炎.
主要方法:
- 一份病例报告显示,一名47岁的男性患有IV期口腔状细胞癌.
- 诊断工作包括实验室检测,超声波,磁共振胆血管细胞造影和PET/CT.
- 治疗涉及永久停药的sintilimab,全身甲基prednisolone,和胰岛素治疗.
主要成果:
- 患者表现为疲劳,食欲下降以及肝酶,葡萄糖和脂酶的升高.
- 图像检测显示胰腺胆道狭窄/封闭和胰腺胀与增加的葡萄糖代谢.
- 患者在使用类固醇和胰岛素治疗后迅速改善,在20个月的随访后,健康状况持续改善.
结论:
- 与ICI相关的胰腺炎是一种罕见但显著的不良事件.
- 及时诊断和使用皮质类固醇和支持性护理的管理可以带来有利的结果.
- 需要进一步的研究来区分在ICI相关病例中的急性和自身免疫性胰腺炎类表现.
相关概念视频
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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
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