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相关概念视频

In- and Out-Groups01:31

In- and Out-Groups

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People all belong to a gender, race, age, and social economic group. These groups provide a powerful source of our identity and self-esteem (Tajfel & Turner, 1979) and serve as our in-groups. An in-group is a group that we identify with or see ourselves as belonging to.
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In-situ Hybridization02:31

In-situ Hybridization

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In situ hybridization (ISH) is a technique used to detect and localize specific DNA or RNA molecules in cells, tissue, or tissue sections using a labeled probe. The technique was first used in 1969 for the investigation of nucleic acids. It is currently an essential tool in scientific research and clinical settings, especially for diagnostic purposes.
Types of probes and labels
A probe is a complementary strand of DNA or RNA that binds to corresponding nucleotide sequences in a cell. Many...
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Inductors01:11

Inductors

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An inductor is a passive component built to store energy within its magnetic field. It can be fabricated by coiling a wire around a magnetic core. When current is permitted to flow through this inductor, it is observed that the voltage across the inductor is directly proportional to the time rate of change of the current. Mathematically,
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Porin Insertion in the Outer Mitochondrial Membrane01:12

Porin Insertion in the Outer Mitochondrial Membrane

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Porins are beta-barrel proteins translocated to the mitochondrial outer membrane through the TOM complex into the intermembrane space. Porin precursors bind TIM chaperones within the intermembrane space and are guided to the Sorting and Assembly Machinery complex or SAM complex on the outer mitochondrial membrane.
Three models describe the assembly of porins by the SAM complex and their insertion into the outer membrane. Model 1 suggests that porins are assembled outside the SAM channel as the...
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In-vitro Mutagenesis01:16

In-vitro Mutagenesis

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To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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X-Inactivation01:58

X-Inactivation

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The human X chromosome contains over ten times the number of genes as in the Y chromosome. Since males have only one X chromosome, and females have two, one might expect females to produce twice as many of the proteins, with undesirable results.
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相关实验视频

Updated: Jul 27, 2025

An in vivo Assay to Test Blood Vessel Permeability
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An in vivo Assay to Test Blood Vessel Permeability

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在这里,在这里,在这里.

Xue-Ling Yang1, Chun-Xuan Wang1, Jia-Xing Wang2

  • 1Department of Nephrology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Frontiers in pharmacology
|June 5, 2023
PubMed
概括

普鲁内拉 (Prunella vulgaris) 可能为COVID-19相关的急性损伤 (AKI) 提供一种天然治疗方法. 它的化合物,如氨酸,通过准参与NF-κB途径的关键基因,显示出潜在的基因潜力,这表明脏并发症的新植物疗法.

关键词:
在 COVID-19 疫情中,急性脏损伤急性脏损伤细胞因子风暴是什么意思分子对接的分子对接.网络药理学 网络药理学

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In vivo and In vitro Rearing of Entomopathogenic Nematodes Steinernematidae and Heterorhabditidae
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相关实验视频

Last Updated: Jul 27, 2025

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科学领域:

  • 草药是一种草药.
  • 药理学 药理学是指药理学的学科.
  • 生物信息学是一种生物信息学.

背景情况:

  • 与COVID-19相关的急性损伤 (AKI) 是死亡率和慢性病的重要危险因素.
  • 普鲁内拉 (Prunella vulgaris L.) 是一种传统的中国草药,在治疗病方面有着悠久的历史.

研究的目的:

  • 调查普鲁内拉尔加里斯 (Prunella vulgaris) 对COVID-19的保护潜力.
  • 通过网络药理学和生物信息学探索潜在机制.

主要方法:

  • 网络药理和生物信息学分析.
  • 蛋白质与蛋白质相互作用网络和丰富分析.
  • 分子对接和动力学模拟.

主要成果:

  • 已经确定了八个关键的向基因 (VEGFA,ICAM1,IL6,CXCL8,IL1B,CCL2,IL10,RELA).
  • 验证了奎尔素,黄素和凯姆菲罗尔与这些标的结合.
  • 突出了IL6,VEGFA和RELA作为抑制NF-κB通路的潜在目标.

结论:

  • 普鲁内拉和其化合物,特别是奎尔塞丁,显示出作为COVID-19 AKI的植物治疗方法的希望.
  • 这项研究提供了针对NF-κB通路的形证据.
  • 需要进一步的研究来验证这些发现 in vivo.