脑卒中后静脉血栓栓塞和中性粒细胞激活:一个插图回顾
Nirav Dhanesha1, Junaid Ansari2, Nilesh Pandey1
1Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, USA.
Research and practice in thrombosis and haemostasis
|June 5, 2023
概括
患有急性缺血性中风的患者面临高静脉血栓栓塞 (VTE) 风险. 中性粒细胞过活化有助于VTE,这表明针对中性粒细胞通路的新疗法可以降低风险.
科学领域:
- 神经学 神经学
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
背景情况:
- 急性缺血性中风患者有高风险的静脉血栓塞栓症 (VTE),影响每年在美国约80,000.
- 症状深静脉血栓 (DVT) 发生在约10%的中风患者中,增加死亡率和残疾.
- 目前的静脉瘤预防仅部分有效,并带有出血风险,需要替代治疗.
研究的目的:
- 审查中风后静脉瘤的流行病学和管理.
- 在中风患者中呈现中性粒细胞过活化的证据.
- 探索中性粒细胞介导的机制,有助于中风后静脉瘤.
主要方法:
- 关于中风后静脉瘤的流行病学,管理和机制的文献综述.
- 检查中性粒细胞过活化的临床前和临床证据.
- 对中性粒细胞 - 血小板相互作用和VTE发展中的炎症途径的分析.
主要成果:
- 中性粒细胞是缺血性中风的早期反应者,在静脉瘤发育中发挥关键作用.
- 中性粒细胞过度活化,通过诸如NET形成和炎症媒介释放等机制,增强了血栓的传播.
- 证据支持中风诱导的中性粒细胞激活与增加静脉瘤风险之间的联系.
结论:
- 中性粒细胞过活化是中风后静脉瘤的一个重要因素.
- 了解中性粒细胞激活途径可能会为中风患者带来新的VTE治疗方法.
- 针对中性粒细胞介导机制提供了一个有前途的策略,以减少这一群体的VTE风险.
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