辐射诱导的循环microRNA与放射治疗后的心声回声学参数相关
Justyna Chałubińska-Fendler1, Zuzanna Nowicka2, Izabela Dróżdż3
1Department of Radiotherapy, Military Institute of Medicine - National Research Institute, Warsaw, Poland.
Frontiers in oncology
|June 5, 2023
概括
乳腺癌放射治疗后循环中的microRNAs (miRNAs) 的短期变化可能预测心脏功能障碍. 特定的miRNAs,包括miR-29c,miR-451和miR-424,与心脏测量显示相关性,为辐射诱导的心脏损伤提供了潜在的生物标志物.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 胸部癌症的放射治疗带来了心脏损伤的风险.
- 识别患有心脏并发症高风险的患者是具有挑战性的.
- 循环中的微RNA (miRNA) 是疾病状态的潜在生物标志物.
研究的目的:
- 调查循环miRNA表达的短期变化是否与乳腺癌放射治疗后的心脏功能障碍相关.
- 确定特定的miRNAs,可以作为辐射诱导心脏损伤的预测生物标志物.
主要方法:
- 研究了两组患者队列 (N=28和N=56),接受左侧乳腺癌放射治疗.
- 血清样本在放射治疗前 (RT),放射治疗后24小时和放射治疗后1个月收集.
- 心脏回声心脏成像在RT后2.5-3年进行;使用向qPCR和752-miRNA面板分析miRNA表达.
主要成果:
- 七个miRNA在RT后表达有显著的变化,与剂量-体积组图指标相关.
- 在验证队列中,miR-15b-5p,miR-22-3p,miR-424-5p和miR-451a的表达在RT后24小时下降.
- miR-29c,miR-451和miR-424与左心室末端透气直径相关,通过多变量分析证实.
结论:
- 循环中的miRNAs的一个子集可以预测放射治疗的乳腺癌患者的心脏功能受损.
- 这些已识别的miRNA显示出潜在的辐射诱导心脏毒性的早期生物标志物.
- 需要进一步的临床观察来确认它们在预测主要临床终点方面的有用性.
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