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两者之间的关联

Jinyu Li¹, Xiajie Zhou², Lixi Li³

¹School of Basic Medical Sciences & The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.

Frontiers in oncology

|June 5, 2023

概括

周围血液中CTSZ基因甲基化的改变与乳腺癌 (BC) 风险有关,特别是在年轻女性中. 低甲基化CTSZ可以作为早期BC检测的潜在生物标志物.

科学领域:

遗传学和表观遗传学
在瘤学瘤学.
生物标志物发现发现

背景情况:

以前的研究表明,外周血液中的DNA甲基化与乳腺癌 (BC) 之间存在潜在的关联.
在外周血液中Cathepsin Z (CTSZ) 基因的甲基化状态需要进一步调查其与BC的联系.

研究的目的:

调查CTSZ基因的外周血液DNA甲基化水平与乳腺癌 (BC) 风险之间的关联.
探索CTSZ甲基化作为中国人口早期BC的潜在生物标志物.

主要方法:

一项病例控制研究涉及567例BC病例,635例健康对照和303例良性乳腺疾病 (BBD).
在外周血液DNA中CTSZ基因的七个CpG位点的甲基化水平的定量确定,使用质谱学.
后勤回归分析,以评估CpG站点对BC风险的概率比率 (OR).

主要成果:

与健康对照组相比,七个CTSZ CpG站点中的五个显示出与BC风险相关的显著低甲基化.
减少CTSZ_CpG_1,CTSZ_CpG_5和CTSZ_CpG_7,8的甲基化与BC风险增加有关,特别是在早期的BC和50岁以下的女性中.
与BBD相比,在BC观察到较低的CTSZ甲基化水平,在甲基化和瘤特征之间发现了相关性.

结论:

周围血液中CTSZ甲基化的改变与乳腺癌风险有关.
特定的CTSZ低甲基化模式可以作为早期BC的潜在生物标志物,特别是在年轻女性中.
需要进一步的研究来验证CTSZ甲基化作为乳腺癌的诊断或预后工具.

关键词:

在CTSZZ中.中国妇女,中国妇女.通过DNA甲基化.乳腺癌乳腺癌乳腺癌个案控制研究研究.

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