COVID-19 和淋巴细胞疾病
Nattawat Klomjit1, Ladan Zand2, Lynn D Cornell3
1Division of Nephrology and Hypertension, University of Minnesota, Minneapolis, Minnesota, USA.
Kidney international reports
|June 5, 2023
概括
COVID-19可能会导致脏损伤,缩性球病变 (COVAN) 是一个常见的并发症,特别是在那些具有高风险APOL1基因型的人群中. 治疗需要仔细考虑免疫抑制的风险和益处,因为结果仍然很差.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 遗传学 是一个遗传学.
背景情况:
- COVID-19是一种系统性疾病,影响多个器官,包括脏.
- 损伤是一种常见的并发症,在高达40%的患者中观察到.
- 各种质细胞疾病与COVID-19有关,因果关系各不相同.
研究的目的:
- 审查和分析与COVID-19相关的质细胞疾病.
- 为了区分COVID-19相关的和偶然的球病理.
- 突出COVID-19相关病 (COVAN) 的流行率和特征.
主要方法:
- 在COVID-19患者中报告的淋巴细胞疾病的文献综述.
- 对COVID-19关联的机理性可信性的分析.
- 识别风险因素,例如COVAN中的APOL1基因型.
主要成果:
- 缩性淋巴细胞病变 (COVAN) 是最常见的,通常与高风险的APOL1基因型有关.
- 其他已报告的疾病包括皮质细胞病,膜性病,半月状丸炎和血栓式微血管病.
- 患者经常出现急性损伤或尿路异常后COVID-19诊断.
结论:
- 与COVID-19相关的淋巴细胞疾病,特别是COVAN,需要谨慎管理.
- 治疗决策,特别是关于免疫抑制的决定,必须平衡风险和益处.
- 短期结果通常很差,强调需要进一步进行长期结果研究.
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