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相关概念视频

Renal Corpuscle01:20

Renal Corpuscle

2.9K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
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Nephrons01:10

Nephrons

3.1K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
3.1K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

10
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
10
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

46
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
46
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

37
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
37
Glomerular Filtration Rate and its Regulation01:28

Glomerular Filtration Rate and its Regulation

3.0K
The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
3.0K

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相关实验视频

Updated: Jul 27, 2025

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
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An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

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COVID-19 和淋巴细胞疾病

Nattawat Klomjit1, Ladan Zand2, Lynn D Cornell3

  • 1Division of Nephrology and Hypertension, University of Minnesota, Minneapolis, Minnesota, USA.

Kidney international reports
|June 5, 2023
PubMed
概括

COVID-19可能会导致脏损伤,缩性球病变 (COVAN) 是一个常见的并发症,特别是在那些具有高风险APOL1基因型的人群中. 治疗需要仔细考虑免疫抑制的风险和益处,因为结果仍然很差.

关键词:
科万 (Covan) 是一个非常有趣的人.在 COVID-19 疫情中,这就是SARS-CoV-2病毒.缩的焦点细分球膜炎.淋巴细胞疾病是什么?球体隆基尼弗里斯 (glomerulonephritis) 是一种发生在人体中的疾病.

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Assessment of Kidney Function in Mouse Models of Glomerular Disease
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Assessment of Kidney Function in Mouse Models of Glomerular Disease

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Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins
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Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins

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相关实验视频

Last Updated: Jul 27, 2025

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

13.8K
Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

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科学领域:

  • 腎臟病學 (nephrology) 是一種醫學專業.
  • 传染性疾病 传染性疾病
  • 遗传学 是一个遗传学.

背景情况:

  • COVID-19是一种系统性疾病,影响多个器官,包括脏.
  • 损伤是一种常见的并发症,在高达40%的患者中观察到.
  • 各种质细胞疾病与COVID-19有关,因果关系各不相同.

研究的目的:

  • 审查和分析与COVID-19相关的质细胞疾病.
  • 为了区分COVID-19相关的和偶然的球病理.
  • 突出COVID-19相关病 (COVAN) 的流行率和特征.

主要方法:

  • 在COVID-19患者中报告的淋巴细胞疾病的文献综述.
  • 对COVID-19关联的机理性可信性的分析.
  • 识别风险因素,例如COVAN中的APOL1基因型.

主要成果:

  • 缩性淋巴细胞病变 (COVAN) 是最常见的,通常与高风险的APOL1基因型有关.
  • 其他已报告的疾病包括皮质细胞病,膜性病,半月状丸炎和血栓式微血管病.
  • 患者经常出现急性损伤或尿路异常后COVID-19诊断.

结论:

  • 与COVID-19相关的淋巴细胞疾病,特别是COVAN,需要谨慎管理.
  • 治疗决策,特别是关于免疫抑制的决定,必须平衡风险和益处.
  • 短期结果通常很差,强调需要进一步进行长期结果研究.