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在骨髓细胞表达的触发受体的高表达1预测了质母细胞瘤的不良预后

Ke Ma¹, Qianqian Guo¹, Xianwei Zhang²

¹Department of Medical Oncology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, People's Republic of China.

OncoTargets and therapy

|June 5, 2023

概括

在质母细胞瘤 (GBM) 中,质母细胞细胞1 (TREM-1) 上表达的触发受体的高表达表明预后不佳,并与免疫抑制性瘤微环境有关. 准TREM-1可能会改善GBM免疫反应.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
基因组学就是基因组学.

背景情况:

质母细胞瘤 (GBM) 是一种具有有限治疗选择的侵袭性脑瘤.
在GBM病变发生过程中,肌肉细胞1 (TREM-1) 上表达的触发受体在GBM病变发生过程中的作用尚不清楚.

研究的目的:

调查TREM-1在GBM中的表达.
为了确定TREM-1在GBM患者的预后意义.
探索TREM-1与GBM中的瘤免疫微环境的关联.

主要方法:

在91个GBM患者样本中对TREM-1进行免疫组合化学分析.
使用GEPIA,TCGA和CGGA数据库进行TREM-1表达和预后的生物信息分析.
使用CIBERSORT和TIMER进行瘤透免疫细胞 (TIIC) 和免疫瘤评分的评估.
分析TREM-1与免疫检查点基因 (ICG) 的相关性.

主要成果:

在GBM组织中,TREM-1表达显著上调.
高TREM-1表达与GBM患者的不良预后相关.
在高TREM-1 GBM中观察到中性粒细胞和巨细胞的透增加.
TREM-1与免疫力学得分和免疫抑制性ICG积极相关.

结论:

高TREM-1表达是GBM的一个独立的不良预后因素.
在GBM中,TREM-1有助于免疫抑制瘤微环境.
阻断TREM-1可能是增强抗GBM免疫力的潜在治疗策略.

关键词:

在TREM-1中,质母细胞瘤 (glioblastoma) 是一种免疫检查点基因免疫检查点基因预后预后预后瘤透免疫细胞的免疫细胞.

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