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在食道疾病中食道微生物群
Qian Zou1, Lijuan Feng1, Xunchao Cai1
1Department of Gastroenterology and Hepatology, Shenzhen University General Hospital, Shenzhen, China.
Frontiers in cellular and infection microbiology
|June 5, 2023
概括
食道菌群的组成在诸如GERD,Barrett等疾病中显著不同.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 内镜的进步增加了食道疾病的诊断,但病原性仍然不清楚.
- 肠道菌群在肠道疾病中的作用促使人们对食道菌群进行研究.
- 了解食道微生物群对于疾病的发病,诊断和治疗至关重要.
研究的目的:
- 审查正常的食道菌群及其在各种食道疾病中的变化.
- 为了比较胃食道逆流 (GERD),巴雷特食道,eosinophilic食道炎和正常状态中的食道微生物组成.
- 为了识别食道癌的微生物生物标志物.
主要方法:
- 对食道菌群研究的文献综述.
- 在不同的食道疾病中对微生物群组成进行比较分析.
- 识别与食道癌相关的潜在微生物生物标志物.
主要成果:
- 在GERD,巴雷特食道,eosinophilic食道炎和正常食道之间存在食道微生物组成的明显差异.
- 正常的食道菌群是格拉姆阳性 (流感菌占主导地位);食道炎菌群是格拉姆阴性占主导地位.
- 食道癌患者的食道菌群多样性显著减少.
- Fusobacterium nucleatum与食道状细胞癌的病理和临床阶段有关.
结论:
- 食道菌群的组成因疾病状况而有很大变化.
- 微生物变化,包括减少多样性和特定细菌,如Fusobacterium nucleatum,与食道癌有关.
- 食道菌群具有早期诊断和治疗策略的潜力.
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