血糖变化和心房的风险:一个元分析
Wei Li1, Yang Wang1, Guoqiang Zhong1
1Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Frontiers in endocrinology
|June 5, 2023
概括
高血糖变化 (GV) 与成人心房风险增加有关. 这一系统性审查和元分析证实了GV作为AF发展的潜在预测因素.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 血糖变化 (GV) 与糖尿病患者的血管并发症有关.
- GV与心房动 (AF) 风险之间的关联需要进一步澄清.
研究的目的:
- 进行系统审查和元分析,评估GV与AF风险之间的关系.
主要方法:
- 为了进行纵向后续研究,对主要数据库 (Medline,Embase,Web of Science,Wanfang,CNKI) 进行了全面的搜索.
- 包括9项包括6,877,661名参与者的队列研究.
- 采用随机效应模型来合成数据并评估异质性.
主要成果:
- 分析显示,高GV与增加AF风险显著相关 (RR: 1.20,95% CI: 1.11-1.30).
- 亚组分析显示了前性和后性研究,糖尿病和非糖尿病人群以及不同的GV测量持续时间之间一致的关联.
- 根据研究质量,没有观察到关联的显著差异.
结论:
- 高血糖变异性可能成为一般成人群体中心房动的预测标志物.
- 进一步的研究可能会探索GV在AF病变发生过程中的机械联系和临床影响.
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