基因组流行病学和抗菌素耐药性概况的基因组流行病学
Chunhui Shu1, Jiaqiang Zhou2, Hongqiong Yu1
1Department of Laboratory Medicine, Ningbo Mingzhou Hospital, Ningbo, People's Republic of China.
Infection and drug resistance
|June 5, 2023
概括
艰难菌株ST3和ST54在医院中呈现传播现象,这凸显了分子监测的必要性. 在这项研究中没有检测到高病毒性菌株 ribotyping 027.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 困难性闭膜炎是与抗生素相关的腹和伪膜肠炎的重要原因.
- 在中国,对于Clostridioides difficile感染 (CDI) 的多医院流行病学数据有限.
研究的目的:
- 研究C. difficile菌株的抗菌素敏感性概况和基因组流行病学.
- 了解C. difficile在多医院环境中的传播动态.
主要方法:
- 从2020年6月到2020年11月进行的前性研究.
- 从七家三级医院的住院腹患者中分离和分析了177种C. difficile菌株.
- 抗微生物敏感性测试和全基因组测序用于基因组流行病学.
主要成果:
- 主要的毒素概况是tcdA+tcdB+ (84.2%) 和tcdA-tcdB+ (15.8%).
- 对克林达米辛,红色胺素,勒沃素和莫西素的高耐药率;对甲尼达和万科米辛的敏感性.
- 序列类型ST3 (26.2%) 和ST54 (16.9%) 是最常见的,有医院内和医院间传播的证据. 没有检测到高病毒性核型 027 (ST1) 菌株.
结论:
- ST3和ST54菌株能够在医院传播,因此需要加强分子流行病学监测.
- 建议在主要医院部门对C. difficile患者进行有针对性的查.
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