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童年功能的种族差异:出生在布拉德福德的队列脏研究
Nida Ziauddeen1,2, Robin F Jeffrey3, Dagmar Waiblinger3
1School of Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton, UK.
Wellcome open research
|June 5, 2023
概括
南亚儿童在青春期前脏功能没有显著的种族差异,尽管胎儿脏尺寸较小. 需要进一步的纵向研究来追踪脏健康和血压在发育过程中.
科学领域:
- 儿科脏病学 儿科脏病学
- 公共卫生 公共卫生
- 遗传学和基因组学 遗传学和基因组学
背景情况:
- 与白人欧洲人相比,南亚人表现出更高的末期功能衰竭率.
- 低出生体重,在南亚人中更为普遍,与成人慢性病有关.
- 以前在布拉德福德出生 (BiB) 队列中的研究结果表明,南亚人胎儿脏尺寸较小.
研究的目的:
- 调查早期儿童功能和血压的种族差异.
- 为了确定胎儿脏大小是否影响这些种族差异.
- 分析血清肌素,囊素C,尿素和尿路标记物 (ACR,PCR,RBP) 与种族相关.
主要方法:
- 在BiB随访中分析了1591名儿童 (7-11岁) 的血液和尿液样本.
- 根据父母的自我报告,种族被归类为白人欧洲人或南亚人.
- 使用已确定的方程 (Schwartz,Zappitelli,Filler) 计算估计的膜过率 (eGFR);对关联进行线性回归.
主要成果:
- 平均eGFR在不同族群之间是可比的 (例如,使用Schwartz的92ml/min/1.73m2).
- 慢性病 (CKD) 的患病率很低;2.4%的尿白蛋白与肌素比率 (ACR) 升高.
- 南亚儿童的腹压血压较高,但在调整后,这在统计学上没有显著意义. 在调整后的模型中,没有发现eGFR或尿路标记物的显著种族差异.
结论:
- 在青春期前的功能中没有观察到任何显著的种族差异,尽管胎儿体积有记录的差异.
- 这项研究强调了需要进行纵向随访,以了解功能和血压在青春期发展的种族模式.
- 在这个群体中,早期儿童的脏健康似乎没有受到种族的影响,这与成年人的趋势相反.
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