连续使用PD-1抑制剂和 cetuximab 会导致肺炎
Makoto Arai1,2, Mitsuhiro Abe3, Shinsuke Kitahara3
1Department of Medical Oncology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
使用抗EGFR抗体和PD-1抑制剂的连续治疗经常导致药物诱导的肺损伤 (DLI). 在接受 cetuximab 和 PD-1 抑制剂的头癌患者中观察到这种风险. 需要进一步的研究来理解这种关联.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 严重的药物诱导性肺损伤 (DLI) 是已知的风险与顺序性 osimertinib 和 PD-L1 抑制剂.
- 序列抗EGFR抗体和PD-1抑制剂治疗与DLI风险之间的关联尚未得到充分理解.
研究的目的:
- 为了研究头癌患者的DLI发病率,这些患者被顺序治疗 cetuximab (一种抗EGFR抗体) 和PD-1抑制剂.
主要方法:
- 在2014-2020年期间治疗的179名头癌患者的回顾性评估.
- 患者被分为三个组:序列式 cetuximab 和 PD-1 抑制剂 (C+P 组),仅 cetuximab (C 组) 和仅 PD-1 抑制剂 (P 组).
- 在不同组中分析了肺炎 (DLI) 发生率和临床特征.
主要成果:
- 在C+P组中,DLI的发病率为18.6%,C组为7.9%,P组为11.4%.
- 之前使用免疫检查点抑制剂 (ICI) 并没有增加DLI风险.
- 连续的PD-1抑制剂和抗EGFR抗体治疗经常与DLI相关.
结论:
- 连续使用PD-1抑制剂和抗EGFR抗体,如 cetuximab,经常与头癌患者的药物诱导肺损伤有关.
- 这种组合疗法需要仔细监测肺毒性.
更多相关视频
09:17A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
Published on: January 2, 2017
07:30Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
相关概念视频
Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Pneumonia II: Pathophysiology
Pneumonia V: Nursing management and Prevention
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
Pneumonia III: Complications and Assessment
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
