癌症患者中NT-proBNP的水平
Jozef Chovanec1,2,3, Jozef Chovanec2,3, Michal Chovanec1
12nd Department of Oncology, Faculty of Medicine, Comenius University and National Cancer Institute, 83310 Bratislava, Slovak Republic.
Oncology letters
|June 5, 2023
概括
在癌症患者中,N-终端B型亲尿素 (NT-proBNP) 水平升高与疾病进展和预后差相关. 在治疗期间监测NT-proBNP可能会提供对整体生存结果的见解.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 生物标志物 生物标志物
背景情况:
- 性尿素,包括N-终端亲B型性尿素 (NT-proBNP),可以由癌细胞产生.
- NT-proBNP的合成可能会受到益炎性细胞因子的刺激,并且在环素化疗期间作为心肌损伤的标记物.
- 这项研究研究了NT-proBNP在没有心脏症状的癌症患者身上,以了解其与疾病特征的关联.
研究的目的:
- 分析接受治疗的癌症患者NT-proBNP水平与患者/疾病特征之间的关联.
- 评估NT-proBNP作为这一群体的整体存活时间 (OS) 的潜在预后标志物.
主要方法:
- 一项临床研究涉及112名接受抗癌治疗的癌症患者.
- 通过免疫化学方法采集了治疗前,治疗后和一年后的外周血液样本,以检测NT-proBNP.
- 对NT-proBNP水平的分析与患者人口统计学,疾病阶段和整体存活率相关.
主要成果:
- 从基线 (561.0±75.1 ng/l) 到治疗后 (1,565.4±461.1 ng/l) 和一年的随访 (1,940.7±581.1 ng/l) 的平均NT-proBNP水平显著增加.
- 在老年患者和患有进展性转移性疾病的患者中观察到高NT-proBNP水平.
- 与高水平NT-proBNP患者相比,在治疗后和一年的随访中,没有升高NT-proBNP的患者的生存状况明显改善 (HR分别为0.47和0.29).
结论:
- NT-proBNP水平与瘤疾病的程度有关,特别是进展性转移性疾病.
- 在治疗期间和治疗后NT-proBNP升高表明预后较差,总生存时间较短.
- 基线NT-proBNP没有被发现是OS的预后,这表明治疗期间的动态变化更具信息性.
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