应对伤寒:消除伤寒发烧作为全球健康问题
Jessie Chen1, Jessica E Long1, Kirsten Vannice1
1Enteric and Diarrheal Diseases, Global Health, Bill & Melinda Gates Foundation, Seattle, Washington, USA.
Open forum infectious diseases
|June 5, 2023
概括
伤寒联合疫苗 (TCV) 对伤寒发烧提供高水平的保护,对儿童是安全的,并对抗抗菌素耐药性. 在改善卫生条件的同时,加快TCV引入对于控制和消除伤寒至关重要.
科学领域:
- 全球健康 全球健康
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
背景情况:
- 伤寒热仍然是全球主要的卫生挑战,特别是在缺乏足够的水和卫生基础设施的地区.
- 通过国际合作,在了解疾病负担和监测工具,包括环境监测方面取得了进展.
- 目前有两种伤寒结合疫苗 (TCV) 获得了世卫组织的预资格,更多的疫苗正在开发中.
研究的目的:
- 评估伤寒联合疫苗 (TCVs) 提供的疗效,安全性和保护持续时间.
- 评估TCVs在打击与伤寒相关的抗微生物耐药性的潜力.
- 倡导在高负担地区加快TCV引入.
主要方法:
- 在为伤寒热流行的国家进行了多项TCV疗效试验.
- 监测疫苗的安全性,特别是在幼儿中.
- 评估了TCVs提供的保护的持久性.
主要成果:
- 转型型冠状病毒对伤寒发烧有很高的保护作用.
- 发现疫苗在幼儿中使用是安全的.
- 数据表明,TCVs提供了持久的保护,并可以帮助解决抗菌素耐药性问题.
结论:
- 伤寒联合疫苗是预防伤寒发烧的安全有效工具.
- 持续投资于水,环境卫生和卫生 (WASH),加上快速推广TCV,对于消除伤寒至关重要.
- 在高负担地区加速TCV引入是全球卫生倡议的关键下一步.
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