胆固醇水平,高血压和MTHFR C677T基因型:一个复杂的相互作用
Cynthia Al Hageh1, Eman Alefishat1,2,3, Michella Ghassibe-Sabbagh4
1College of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates.
Heliyon
|June 5, 2023
概括
高水平的homocysteine会增加高血压和中风风险. 甲基四叶酸还原酶 (MTHFR) 的T等位基因和TT基因型与更高的同等氨酸,高血压和中风风险有关,特别是在利尿剂使用时.
科学领域:
- 遗传学和心血管健康
- 生物化学和疾病风险
- 药物基因组学 药物基因组学
背景情况:
- 高水平的同类氨酸是高血压和中风的已知危险因素.
- 甲基四基叶酸减少酶 (MTHFR) 酶在同类氨酸代谢中起着关键作用.
- 在MTHFR基因中的C677T多态可能会影响同类氨酸水平和相关的健康风险.
研究的目的:
- 为了研究与MTHFR C677T基因型相关的同型素水平.
- 为了检查同等氨酸,高血压,中风和抗高血压药物的使用之间的关联.
- 识别潜在的基因型特异性风险和治疗影响.
主要方法:
- 在2,640名黎巴嫩成年人中对MTHFR C677T多态的基因定型.
- 测量血同型半氨酸水平.
- 记录高血压,中风病史和药物使用情况.
主要成果:
- 在患有高血血和高血压的患者中,MTHFR TT基因型和T等位基因更为普遍.
- 高血压患者,特别是服用利尿剂的患者,表现出显著更高的同类半氨酸水平.
- 在MTHFR T等位基因携带者中,同类半氨酸水平与中风风险相关.
结论:
- 在具有MTHFR T等位基因和TT基因型的个体中,同型氨酸,高血压,药物使用和中风风险之间存在关联.
- 利尿剂治疗与homocysteine水平的增加有关,这表明需要监测和管理.
- 在服用利尿剂的患者中,常规测量和控制类型的同类半氨酸可能会改善健康结果.
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