精子中的会通过稳定地与细胞膜结合,影响人类精子的运动性
Claudia Pappalardo1, Ilaria Cosci2, Giulia Moro3
1Department of Medicine, Unit of Andrology and Reproductive Medicine, University of Padova, Padova, Italy.
Frontiers in cell and developmental biology
|June 5, 2023
概括
环境 (Cd) 暴露显著降低了人类精子的运动性,并积聚在精子细胞中. 减少环境中的Cd暴露是缓解生殖健康问题的关键.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 人类生育能力的人类生育能力
背景情况:
- 全球生育率正在下降,环境污染物被认为是主要的因素.
- 重金属 (Cd) 已知具有生殖毒性,但其在人类精子中的直接积累仍未得到充分研究.
研究的目的:
- 调查 (Cd) 暴露对人类精子功能的直接影响.
- 分析 (Cd) 在人类精子细胞中的细胞积累和分布.
主要方法:
- 来自高与低环境 (Cd) 暴露区域的男性的精液样本的比较.
- 在精液和精子细胞中的 (Cd) 的量化使用诱导合血 (ICP) 光谱学.
- 使用扫描电子显微镜与能量分散光谱学 (SEM-EDS) 评估 (Cd) 在精子中的分布;还进行了体外暴露实验.
主要成果:
- 在高 (Cd) 暴露区域的男性表现出更高的精液 (Cd) 水平和减少的总运动精子分数.
- 精液中的 (Cd) 含量与精子头和子上检测到的 (Cd) 有显著的相关性.
- 实验室 (Cd) 暴露减少了精子的渐进性运动性;测试的清理剂没有恢复运动性.
结论:
- (Cd) 直接积聚在人类精子细胞中,损害精子的功能和运动.
- 减少环境中的 (Cd) 暴露是解决引起的生殖问题的首要策略.
更多相关视频
19:26Measuring Intracellular Ca2+ Changes in Human Sperm using Four Techniques: Conventional Fluorometry, Stopped Flow Fluorometry, Flow Cytometry and Single Cell Imaging
Published on: May 24, 2013
20.3K
09:47Recording Electrical Currents across the Plasma Membrane of Mammalian Sperm Cells
Published on: February 14, 2021
2.7K
相关概念视频
Spermatogenesis
102.7K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.7K
Structure of Cadherins
3.4K
The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins” is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This...
3.4K
