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使用基因型数据的美国鱼种群基因组学

Guoyu Hu¹, Duy Ngoc Do¹, Ghader Manafiazar¹

¹Department of Animal Science and Aquaculture, Dalhousie University, Truro, NS, Canada.

Frontiers in genetics

|June 5, 2023

概括

美国子的基因组选择需要了解遗传结构. 这项研究分析了链接不平衡 (LD) 和种群遗传学,揭示了低多样性和三个祖先群体,这些群体对于高效的育种计划至关重要.

科学领域:

动物遗传学动物遗传学
人口基因组学是人口的基因组学.
养殖家禽动物的繁殖.

背景情况:

在家禽中有效的基因组选择程序取决于了解种群遗传结构.
美国子 (Neovison vison) 是有价值的毛皮动物,但它们的遗传多样性和结构需要详细的研究来实现繁殖的进步.

研究的目的:

为了计算链接不平衡 (LD) 模式,有效种群大小 (Ne),遗传多样性,遗传距离和美国鱼种群结构.
为了确定单核酸多态度 (SNP) 的最佳数量,以实现精确的基因组选择.
在不同颜色类型中划分遗传结构和祖先组件.

主要方法:

通过Affymetrix Mink 70K面板对来自两个农场的2,973只美国鱼进行基因定型.
对链接不平衡 (LD) 模式,有效种群大小 (Ne),遗传多样性和种群差异化的分析.
应用人口结构分析来识别祖先遗传群体.

主要成果:

LD模式表明,需要至少7700个 (CCFAR) 和4200个 (MFF) 的SNP来进行精确的基因组选择.
五代前估计的有效人口规模 (Ne) 是76 (CCFAR) 和91 (MFF).
鱼种群表现出较低的遗传多样性,颜色类型中最多的变异;确定了三个祖先遗传群体,特定的颜色类型集群或混合.

结论:

该研究使用中密度SNP面板提供了美国子的基本遗传信息.
了解种群结构和LD对于开发有效的基因组选择策略至关重要.
结果突出了美国子颜色类型之间的密切遗传关系和低多样性,为未来的育种工作提供了信息.

关键词:

美国美子美子.实际人口规模实际人口规模基因型基因型基因型链接不平衡的关系人口基因组学人口基因组学

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