敏感性模式和病毒性基因型的病毒性基因型
Ahmed Morad Asaad1, Gasser El-Azab2, Eman Abdelsameea2
1Department of Microbiology, College of Medicine, Zagazig University, Zagazig 44519, Egypt.
World journal of gastroenterology
|June 5, 2023
概括
针对Helicobacter pylori (H. pylori) 感染的14天三重治疗方案显示,埃及患者的根除率低至59.2%. 高的H. pylori对常见抗生素的耐药性,如美特罗尼达,阿莫西西林和澄素,对治疗成功提出了重大挑战.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 胃肠病学 胃肠病学
背景情况:
- 杆菌 (H. pylori) 是一种主要的病原体,引起胃癌,和胃炎.
- 了解H. pylori的流行率和抗生素耐药性对于有效的治疗策略至关重要.
研究的目的:
- 为了确定埃及患者的H. pylori感染频率和耐药性模式.
- 评估H. pylori毒性因子对14天三重治疗成功的影响.
主要方法:
- 研究了72名患有H.pylori暗示性胃肠道问题的患者.
- 分析了使用PCR的caga和vacA基因型.
- 通过组织学和快速尿酶试验评估治疗反应治疗后6周.
主要成果:
- 意图治疗的根除率为59.2%.
- 杆菌耐药率:清素 (52.8%),阿莫西西林 (81.9%),甲尼达 (100%).
- 与 vacA s1 阳性菌株相关的成功根除;与清素和阿莫西西林耐药性相关的根除失败.
结论:
- 14天三重治疗的低根除率令人担忧.
- 广泛存在的H. pylori对美特罗尼达,阿莫西西林和澄素的耐药性使治疗复杂化.
- 迫切需要更新H. pylori治疗指南,考虑到耐药性模式.
更多相关视频
08:03Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
Published on: December 7, 2021
2.2K
10:33Multi-locus Variable-number Tandem-repeat Analysis of the Fish-pathogenic Bacterium Yersinia ruckeri by Multiplex PCR and Capillary Electrophoresis
Published on: June 17, 2019
10.9K
相关概念视频
Factors Affecting the Risk of Infection
12.0K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.0K
Infection
8.4K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
8.4K
Modern Molecular Taxonomy
56
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
56
