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Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes
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敏感性模式和病毒性基因型的病毒性基因型.

Ahmed Morad Asaad1, Gasser El-Azab2, Eman Abdelsameea2

  • 1Department of Microbiology, College of Medicine, Zagazig University, Zagazig 44519, Egypt.

World journal of gastroenterology
|June 5, 2023
PubMed
概括

针对Helicobacter pylori (H. pylori) 感染的14天三重治疗方案显示,埃及患者的根除率低至59.2%. 高的H. pylori对常见抗生素的耐药性,如美特罗尼达,阿莫西西林和澄素,对治疗成功提出了重大挑战.

关键词:
克拉里斯罗米耐药性 克拉里斯罗米耐药性根除疗法是一种根除疗法.在Helicobacter Pylori的研究中,病毒性 病毒性在Caga基因基因.vacA 基因 vacA 基因 基因

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科学领域:

  • 医学微生物学 医学微生物学
  • 传染性疾病 传染性疾病
  • 胃肠病学 胃肠病学

背景情况:

  • 杆菌 (H. pylori) 是一种主要的病原体,引起胃癌,和胃炎.
  • 了解H. pylori的流行率和抗生素耐药性对于有效的治疗策略至关重要.

研究的目的:

  • 为了确定埃及患者的H. pylori感染频率和耐药性模式.
  • 评估H. pylori毒性因子对14天三重治疗成功的影响.

主要方法:

  • 研究了72名患有H.pylori暗示性胃肠道问题的患者.
  • 分析了使用PCR的caga和vacA基因型.
  • 通过组织学和快速尿酶试验评估治疗反应治疗后6周.

主要成果:

  • 意图治疗的根除率为59.2%.
  • 杆菌耐药率:清素 (52.8%),阿莫西西林 (81.9%),甲尼达 (100%).
  • 与 vacA s1 阳性菌株相关的成功根除;与清素和阿莫西西林耐药性相关的根除失败.

结论:

  • 14天三重治疗的低根除率令人担忧.
  • 广泛存在的H. pylori对美特罗尼达,阿莫西西林和澄素的耐药性使治疗复杂化.
  • 迫切需要更新H. pylori治疗指南,考虑到耐药性模式.