肠道微生物组与健康的学龄儿童认知发展的关系
Yelena Lapidot1, Maayan Maya1, Leah Reshef2
1Department of Epidemiology and Preventive Medicine, School of Public Health, the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Frontiers in pediatrics
|June 5, 2023
概括
肠道微生物组与儿童的认知发展有关. 在学龄儿童中,更多样化的肠道微生物组与更高的智力得分 (FSIQ) 相相关.
科学领域:
- 微生物组研究的研究.
- 神经发育科学 神经发育科学
- 儿科卫生健康 儿科卫生健康
背景情况:
- 肠道微生物组在神经发育中的作用正在调查中.
- 现有的证据将肠道微生物组与儿童认知发育联系起来是有限的.
- 这项研究探讨了肠道细菌与学龄儿童认知功能之间的联系.
研究的目的:
- 检查肠道微生物组组成与学龄儿童认知发育之间的关联.
- 研究社会经济地位 (SES) 等因素如何影响这种关系.
- 识别与认知表现相关的特定细菌种群.
主要方法:
- 对165名健康的以色列阿拉伯儿童 (年龄在6-9岁) 的横截面研究.
- 在便样本上使用16S rRNA基因测序进行肠道微生物组分析.
- 通过斯坦福-比内特测试 (全尺度智商系数 - FSIQ) 评估认知功能;统计模型对共变量进行控制.
主要成果:
- 更高的肠道微生物群多样性 (α-多样性) 与增加的FSIQ分数有显著的关联.
- 肠道微生物组组成 (β-多样性) 在很大程度上是由FSIQ得分和SES解释的.
- 包括Prevotella和Bacteroides uniformis在内的特定细菌显示出与FSIQ有显著的关联.
结论:
- 在肠道微生物群和学龄儿童的认知发育之间存在显著的独立关联.
- 肠道微生物群的多样性和组成是影响认知结果的潜在因素.
- 需要进一步的研究来阐明这些关联背后的机制.
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