分子相互作用的分子相互作用
Z Muhsen M Ali1, H Ghaith Sachit2, M Jaafar Hussein3
1Faculty of Dentistry, Al-Rafdain University College, Baghdad (00964), Iraq.
Archives of Razi Institute
|June 5, 2023
概括
在伊拉克患有结肠直肠癌的患者中检测到约翰·坎宁汉病毒 (JCV) DNA和互白素-1β (IL-1β). 较高的JCV感染率和IL-1β表达率表明它们在结直肠癌的发展和进展中的作用.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症死亡的主要原因.
- 约翰·坎宁汉病毒 (JCV) 的血清流行率在成年人中很高 (70-90%),最近与各种恶性瘤有关.
- 介质素-1β (IL-1β) 促进瘤生长,是几个固体瘤的不良预后标志物,包括结肠癌.
研究的目的:
- 调查结直肠癌组织中JCV DNA和IL-1β的存在和一致表达.
- 分析JCV和IL-1β在良性结直肠瘤和健康对照中的关联.
- 探索JCV和IL-1β在伊拉克队列中结直肠腺癌的发病过程中的潜在作用.
主要方法:
- 分析了50名结肠直肠癌患者,30名良性结肠瘤患者和20名对照患者的组织样本.
- 使用染色体在位杂交 (CISH) 进行了JCV DNA检测.
- 通过免疫组织化学 (IHC) 来评估IL-1β表达.
主要成果:
- 在42%的结直肠癌组织和6.7%的良性瘤中检测到JCV DNA;对照组中没有发现JCV.
- 在52%的结直肠癌,43.3%的良性瘤和20%的对照中观察到IL-1β阳性.
- 在结直肠癌患者中观察到高比例的协同JCV感染和IL-1β表达.
结论:
- 该研究表明,在伊拉克患有结直肠腺癌的患者中,JCV DNA的显著存在和IL-1β表达的升高.
- 这些发现表明,JCV和IL-1β在恶性和良性结直肠瘤的发展和进展中可能发挥作用.
- 需要进一步的研究来阐明JCV,IL-1β和结直肠癌之间的关联的具体机制.
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