锡尔图因1表达增强了与喘结合过敏性鼻炎的炎症反应
A Saedan Kutin1, A Jasib Almzaiel1, A Al-Badry2
1Department of Medical Chemistry, College of Medicine, University of AL-Qadisiyah, Al-Diywaniyah, Iraq.
一种蛋白质SIRT1可能在喘和过敏性鼻炎炎症中发挥作用. 在患者中发现SIRT1和CCL11水平升高,这表明与疾病发病和鼻分泌特征的联系.
科学领域:
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
- 生物化学 生物化学
背景情况:
- 喘 (ASTH) 和过敏性鼻炎 (AR) 是已知联系的常见炎症状况.
- SIRT1,一种依赖NAD的III类组素脱乙酶,已与ASTH的发病有关,但其保护作用需要进一步研究.
研究的目的:
- 研究SIRT1在ASTH和AR患者的炎症反应中的作用.
- 探索SIRT1,CCL11和ASTH和AR中的疾病严重程度之间的关系.
主要方法:
- 从30名AR患者的ASTH,40名AR患者的ASTH,40名AR患者的ASTH和30名对照组收集了血液和鼻液样本.
- 使用ELISA分析了全血细胞计 (CBC),中性粒细胞/淋巴细胞比 (N/L),血清和鼻腔SIRT1以及CCL11水平.
主要成果:
- 与其他组相比,AR组的ASTH显示出显著更高的乙氨基酸计数和N/L比率 (P<0.05).
- 在患者组和对照组中观察到血清和鼻腔SIRT1和CCL11水平升高 (P<0.05).
结论:
- SIRT1可能调节CCL11水平,从而影响ASTH的发病性.
- 鼻分泌中的SIRT1代表了肺气道疾病的新型生物标志物,如ASTH.
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