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1Department of Microbiology, College of Veterinary Medicine, University of Basrah, Basrah, Iraq.
Archives of Razi Institute
|June 5, 2023
概括
伊拉克的甲素耐药黄金葡萄球菌 (MRSA) 正在增加. 这项研究在人类,动物和环境样本中确定了MRSA患病率和Spa类型,揭示了广泛的抗生素耐药性.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 分子流行病学分子流行病学
背景情况:
- 甲素耐药黄金葡萄球菌 (MRSA) 导致严重的医院,社区和动物感染.
- 分子类型测定对于调查MRSA疫情和传播动态至关重要.
- 伊拉克MRSA感染病例显著增加,需要进行本地流行病学研究.
研究的目的:
- 确定在伊拉克的人类,动物和环境来源中MRSA的流行率.
- 描述局部MRSA分离物的抗生素耐药性概况.
- 为了确定在耐药MRSA菌株中Spa类型的分布.
主要方法:
- 总共收集了150个样本 (人类,动物,环境).
- 在MRSA鉴定中使用了表型方法和mecA基因检测.
- 通过光盘扩散评估抗生素耐药性;使用PCR和测序进行SPA类型.
主要成果:
- 人类MRSA患病率为80%,牛为67.5%,环境样本为31.3%.
- 所有MRSA分离物都表现出多药性耐药性,对万科米辛的敏感性最高,对青素的敏感性最低.
- 主要的Spa类型是人类和动物隔离物中的t304,t8986和t14870,环境隔离物中的t304/t14870.
结论:
- 在伊拉克,MRSA在人类,动物和环境领域普遍存在,表现出显著的多药耐药性.
- 在该地区,特定的Spa类型 (t304,t8986,t14870) 与MRSA有关.
- 了解遗传变异是控制MRSA出现和传播的关键.
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