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相关概念视频

Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

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Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
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An ideal Y-Y transformer, grounded through neutral impedances, displays per-unit sequence networks akin to those of a single-phase ideal transformer when subjected to balanced positive- or negative-sequence currents. These currents do not produce neutral currents, and their associated voltage drops.
Zero-sequence currents, which are identical in magnitude and phase, generate a neutral current, resulting in voltage drops across the neutral impedance and the low-voltage winding. If the...
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In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
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When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
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RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
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Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER
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不同的私有频段采矿 频段采矿

Shengzhi Xu1, Sen Su1, Xiang Cheng1

  • 1Beijing University of Posts and Telecommunications, Beijing China.

IEEE transactions on knowledge and data engineering
|June 5, 2023
PubMed
概括
此摘要是机器生成的。

本研究介绍了PFS2,这是一种用于私人频序挖矿 (FSM) 的新算法. 通过采样有效地修剪候选序列,PFS2改善了隐私-实用性权衡,通过差异性隐私实现了准确的结果.

关键词:
候选修剪可能发生.不同的隐私差异性隐私.频频频段采矿 频频频段采矿

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科学领域:

  • 计算机科学 计算机科学
  • 数据挖掘 数据挖掘
  • 保护隐私的技术 保护隐私的技术

背景情况:

  • 频繁序列挖掘 (FSM) 对于在序列数据中发现模式至关重要.
  • 在FSM中实现严格的差异隐私在平衡数据实用性和隐私方面存在挑战.
  • 现有的方法在差异性私密的FSM中扎着噪声与候选人比率.

研究的目的:

  • 开发一种新的差异私密频序挖掘 (FSM) 算法,PFS2.2.
  • 通过有效地修剪候选序列,增强FSM中的公用事业-隐私权权衡.
  • 在差异性隐私下引入对一般差距受限制的FSM的支持.

主要方法:

  • 利用基于采样的候选修剪技术,使用样本数据库.
  • 利用样本数据库上的杂局部支持估计来识别可能频繁的序列.
  • 采用差距感知序列缩小,灵敏度计算和值放松以进行准确性和隐私校准.

主要成果:

  • 已经正式证明PFS2是 ε-差异性私密的.
  • 该算法有效地削减了不有前途的候选序列,显著改善了隐私-实用性权衡.
  • 实验表明,在私下发现真实数据集上的频繁序列时,其准确度很高.

结论:

  • PFS2是第一个在差异隐私中支持一般差距受约束的FSM的算法.
  • 拟议的采样和修剪技术有效地减轻了私人FSM中的噪音影响.
  • PFS2为准确和私密的频序发现提供了强大的解决方案.