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相关概念视频

Genomics02:02

Genomics

36.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

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Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
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Next-generation Sequencing03:00

Next-generation Sequencing

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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
91.7K
Genomic DNA in Prokaryotes00:46

Genomic DNA in Prokaryotes

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The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
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Genome Annotation and Assembly03:36

Genome Annotation and Assembly

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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

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Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
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相关实验视频

Updated: Jul 27, 2025

Metagenomic Analysis of Silage
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Metagenomic Analysis of Silage

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基因组和基因组学

Xin-Dong Li1,2, Yi-Cen Lin1,2, Rui-Si Yang1,2

  • 1Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.

Frontiers in microbiology
|June 5, 2023
PubMed
概括
此摘要是机器生成的。

乳酸细菌AACE3是一种新型的乳酸细菌,表现出强大的抗菌和抗氧化特性. 这种菌株显示出用于对抗病原体感染和抗氧化剂生产的潜力.

关键词:
乳制剂公司ibacillus chiayiensis抗微生物活性的抗微生物活性.抗氧化作用 抗氧化作用进行比较的基因组学.进行全基因组测序.

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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
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gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
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Metagenomic Analysis of Silage
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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA

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科学领域:

  • 微生物学 微生物学
  • 基因组学就是基因组学.
  • 食品科学 食品科学 食品科学

背景情况:

  • 乳酸细菌 (LAB) 由于其有益的特性而被广泛使用.
  • 在2018年建立的一种物种Lacticaseibacillus chiayiensis的资源和表征有限.
  • 对新型LAB菌株的全面评估对于扩大其应用至关重要.

研究的目的:

  • 为了描述Lacticaseibacillus chiayiensis AACE3,从发酵的蓝中分离出来.
  • 评估其基因组特征和体外功能性质.
  • 评估其作为益生菌和抗氧化剂生产的潜力.

主要方法:

  • 基因组分析以确定与抗压,粘附和生物膜形成相关的基因.
  • 在体外测试评估抗菌活性对常见的病原体.
  • 评估胃肠道液体的耐受性和抗氧化能力.
  • 研究生物膜的产生和抗氧化活性的来源.

主要成果:

  • 基因组分析揭示了与环境适应,耐压力和粘附相关的基因.
  • L. chiayiensis AACE3对八种重要的病原体表现出强大的抗菌活性.
  • 该菌株在模拟的胃肠道条件下表现出高生存率和强大的抗氧化能力.
  • 细胞外代谢物和酶,而不是完整的细胞,被确定为抗氧化活性的主要来源.

结论:

  • L. chiayiensis AACE3具有显著的抗菌和抗氧化能力.
  • 它承受胃肠道疾病的能力表明益生菌的潜力.
  • 这种菌株的抗氧化特性,来自细胞外因素,提供了新的应用.
  • L. chiayiensis AACE3 是开发功能性食品和对抗感染的有希望的候选者.