在垂直传播的毒素
Logan D Moore1, Matthew J Ballinger1
1Department of Biological Sciences, Mississippi State University, Mississippi State, MS, United States.
Frontiers in microbiology
|June 5, 2023
概括
某些微生物共生体基因,包括核糖体失活蛋白 (RIP) 和OTU类囊蛋白酶 (OTU),对于昆虫垂直传播的共生体的长期稳定性至关重要. 这些领域是共生体进化和持久性的关键.
科学领域:
- 微生物学 微生物学
- 进化生物学 进化生物学
- 基因组学就是基因组学.
背景情况:
- 垂直传播 (VT) 微生物共生体对于昆虫宿主进化至关重要.
- 了解共生动物持久性的遗传基础是一个关键的研究问题.
- 螺旋体中特定的毒素和毒性域与共生生物表型有关,但它们的分布知之甚少.
研究的目的:
- 为了研究毒素和毒性域在Spiroplasma属的分布.
- 确定有助于垂直传播的共生体长期稳定的遗传元素.
- 来自Drosophila atripex. 的一个非操纵性Spiroplasma共生体的基因组分析.
主要方法:
- 来自Drosophila atripex的Spiroplasma共生体的基因组测序.
- 对12个VT和31个非VT的Spiroplasma基因组进行比较基因组分析.
- 在螺旋体和昆虫基因组中对特定域 (RIP,OTU,ankyrins,ETX/MTX2) 的生物信息搜索.
主要成果:
- 核糖体失活蛋白 (RIPs),OTU类囊蛋白酶 (OTUs),基林和ETX/MTX2域在VT Spiroplasma中比非VT菌株更为普遍.
- 仅在VT-Spiroplasma中发现了OTU和ankyrin域.
- 在所有VT Spiroplasma和三个非VT菌株中都存在RIP域,通常与等离子体相关.
结论:
- 包括RIP,OTU和ankyrins在内的保存的一组共生域可能有助于昆虫垂直传播的螺旋的进化和持久性.
- 这些域经常在等离子体上发现,可能有助于共生体的分散和维持.
- 这些发现表明,这些域类型之间在共生虫协会中存在功能相互作用.
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