多次重新排列和小的物种间和物种内部的线粒基因组序列变化在线粒基因组序列的多重重排列和小的物种间和物种内部的线粒基因组序列变化
Kajsa Himmelstrand1, Mikael Brandström Durling1, Magnus Karlsson1
1Uppsala BioCenter, Department of Forest Mycology and Plant Pathology, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Frontiers in microbiology
|June 5, 2023
概括
在五种密切相关的真菌病原体中,线粒体基因组 (线粒体) 进化显示出较低的变异性,频繁重排,但保留了基因. 这表明这些真菌线粒基因组的进化速度缓慢.
科学领域:
- * 菌群学 * 菌群学
- * 进化生物学 进化生物学
- * 基因组学 是一个学科.
背景情况:
- *线粒体是重要的真核细胞器官,参与能量生产和真菌毒性.
- *了解真菌线粒基因组的演变至关重要,特别是在密切相关的物种中.
- * Heterobasidion annosum sensu lato复合体包括影响针叶树的死菌病原体.
研究的目的:
- *分析和比较Heterobasidion annosum sensu lato综合体内的五种物种的线粒基因组.
- *研究基因组和遗传变异,包括重组和基因含量.
- * 评估这个复杂的真菌线粒基因组的进化速度.
主要方法:
- * 测序和分析了来自五种异种基因组的60个线粒基因组.
- *比较基因组分析,重点关注基因顺序,内变异和基因间区域.
- * 识别保存的元素,如回归内核酶基因和基因间的ORF.
主要成果:
- *在物种之间和物种内部观察到的基因组和遗传变异总体较低,尽管有大量的重组.
- *发现了大规模的基因块转位和频繁的基因间重组.
- *因子含量而变化的线粒基因组长度,在物种中发现了保留的子和跨基因的ORF (uORF6,uORF8,uORF9).
- * 一个富含GC的平行列序列存在于不同的数量中.
- *物种内部的变化非常低 (例如,一个内核交换,H. parviporum中0.28%的SNP频率).
结论:
- * Heterobasidion annosum sensu lato复合体在其线粒基因组中表现出缓慢的进化速度.
- *基因组重组很常见,但不会显著影响核心基因的保存.
- * 保存的非编码元素和ORF表明它们在线粒基因组稳定性或进化中的功能重要性和潜在作用.
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