对前突触资源的竞争加剧了干扰记忆的歧视
Chi Chung Alan Fung1,2, Tomoki Fukai2
1Department of Neuroscience, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong, China.
PNAS nexus
|June 5, 2023
概括
突触竞争是成年神经发生的一个过程,有助于将类似的记忆分开. 这种无监督学习机制可能比传统算法具有优势,特别是有限的数据.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 机器学习 机器学习
背景情况:
- 河马中的成年神经发生对于记忆歧视至关重要.
- 突触竞争,一个非局部可塑性规则,在记忆分离中涉及但尚未完全理解.
- 现有的模型通常依赖于像Hebb规则这样的局部可塑性规则.
研究的目的:
- 阐明突触竞争在干扰记忆的模式分离中的作用.
- 研究突触竞争和神经元成熟的独特贡献.
- 探索基于竞争的学习规则的计算优势.
主要方法:
- 在成年神经发生过程中模拟突触竞争.
- 通过竞争分析成年出生神经元的集成.
- 基于竞争的前网络与反向传播训练的MLP进行比较.
主要成果:
- 突触竞争和神经元成熟在分离记忆模式中发挥着不同的作用.
- 使用基于竞争的学习的前网络超过了使用有限样本的反向传播.
- 证明了突触竞争有助于分离类似记忆的机制.
结论:
- 突触竞争是海马体模式分离的一个关键机制.
- 基于竞争的学习为反向传播提供了一个潜在的强大替代方案,特别是在数据稀缺的情况下.
- 突出了神经计算和人工智能的突触竞争的功能影响和潜在应用.
相关概念视频
Interference and Decay
177
Forgetting is a complex cognitive phenomenon influenced by several factors, among which interference and decay are particularly prominent. These processes explain why individuals often struggle to retrieve specific information from memory, leading to lapses in recall that can be observed in everyday situations.
Interference occurs when competing memories hinder the retrieval of particular information. It can be classified into two types: proactive and retroactive interference. Proactive...
Interference occurs when competing memories hinder the retrieval of particular information. It can be classified into two types: proactive and retroactive interference. Proactive...
177
Role of Neurotransmitters in Memory
676
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
676
Role of Cerebellum and Prefrontal Cortex in Memory
508
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
508
Long-term Potentiation
2.8K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
Hebbian LTP
LTP can occur when...
2.8K
Synaptic Signaling
5.7K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
5.7K
Higher Mental Functions of Brain: Learning and Memory
898
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
898


