人类与蝙蝠和蝙蝠冠状病毒的相互作用在科特迪瓦的农村地区
Christian E Lange1,2,3, Julien Kalpy Coulibaly4, Aristide Beranger Ako Ako4
1Metabiota Inc., 425 California Street, San Francisco, CA 94104, USA.
One health (Amsterdam, Netherlands)
|June 5, 2023
概括
研究人员在科特迪瓦的蝙蝠中检测到冠状病毒 (CoV),但没有发现人类感染. 虽然直接的溢出风险很低,但建议对狩猎者和农民等高暴露群体保持持续警.
科学领域:
- 病毒学 病毒学
- 生态生态学 生态生态学
- 公共卫生 公共卫生
背景情况:
- 蝙蝠是众所周知的各种冠状病毒 (CoV) 的存储库,包括α-和β-CoVs.
- 了解蝙蝠-CoV的多样性和传播是至关重要的,尤其是在COVID-19大流行的情况下.
- 人类和野生息地之间的生态环境可以促进动物传播疾病的传播.
研究的目的:
- 检测和描述科特迪瓦的蝙蝠和人类中传播的冠状病毒.
- 评估该地区蝙蝠-CoV传播给人类的可能性.
- 为了确定暴露于蝙蝠传播病毒的风险较高的人类群体.
主要方法:
- 蝙蝠监测:捕获了314只蝙蝠,并为CoV RNA取样.
- 人类监测:综合征和基于社区的监测对401个人进行.
- 病毒检测:聚合酶链反应 (PCR) 用于在蝙蝠和人类样本中检测CoV.
- 对检测到的CoV序列进行了基因分析.
- 风险评估:使用了"分拆"风险排名工具.
主要成果:
- 在0.96%的采样蝙蝠中检测到冠状病毒RNA (314个中的3个).
- 在特定的蝙蝠物种中发现了类似于已知的蝙蝠冠状病毒 (BtKY22,BtKY55/56) 的序列.
- 在被采样的401名人类中没有检测到CoV感染.
- 在参与作物生产,狩猎,捕捉和捕鱼的人群中观察到较高的蝙蝠暴露率.
- "Spillover"工具表示没有迫在眉的风险,但由于宿主范围和病毒特征,建议谨慎使用.
结论:
- 科特迪瓦的蝙蝠种群含有多种冠状病毒.
- 目前的监测没有检测到蝙蝠-CoV对研究的人口的溢出.
- 具有涉及大量蝙蝠接触的职业或娱乐活动的人面临更高的暴露风险.
- 持续的警和进一步的研究是有必要的,以监测来自蝙蝠冠状病毒的潜在动物性疾病威胁.
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