慢性血栓栓塞性肺高血压与计算机断层扫描显示的肺总体体积损失有关
Nanae Tsuchiya1, Yan-Yan Xu2, Junji Ito3
1Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Nishihara 903-0125, Okinawa, Japan. nanae7a50@hotmail.com.
World journal of radiology
|June 5, 2023
概括
慢性血栓栓塞性肺高血压 (CTEPH) 患者在治疗后意外失去肺体积. 这种损失,以及心脏变化,表明CTEPH中正在进行的对酶体重塑.
科学领域:
- 肺部医学 肺部医学
- 放射学 放射学是一门学科.
- 心脏病学 心脏病学
背景情况:
- 慢性血栓栓塞性肺高血压 (CTEPH) 通常表现为正常的肺体积.
- 然而,显著的少数 (20% - 29%) CTEPH 患者在肺功能测试中表现出限制性模式.
研究的目的:
- 量化CTEPH患者肺体积和心脏截面面积 (CSA) 的纵向变化.
- 将这些变化与匹配的对照组进行比较.
主要方法:
- 对15名CTEPH患者和45名对照进行了回顾性队列研究.
- 胸部计算机断层扫描 (CT) 扫描在基线和至少6个月治疗后被分析.
- 测量和比较CT衍生的肺体积和心脏CSA.
主要成果:
- 治疗后,CTEPH患者的总体,右肺和右下叶体积显著减少 (P <0.05).
- 与对照组相比,CTEPH患者的肺体积和心脏CSA的减少显着更大 (P <0.05).
- 在对照组中观察到肺体积和心脏CSA变化之间的负相关性,但在CTEPH患者中没有.
结论:
- 对CTEPH的治疗与肺总体体积意外减少有关.
- 这一发现可能表明,CTEPH患者的肺部中仍在继续进行帕伦基马重塑.
- 需要进一步的研究来了解这些体积变化的影响.
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