在现实世界中,血中异素计数作为慢性阻塞性肺部疾病恶化的预测生物标志物
Moegi Komura1,2, Tadashi Sato1, Yohei Suzuki1,2
1Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-Ku, Tokyo 113-8431, Japan.
Canadian respiratory journal
|June 5, 2023
概括
周围血液中乙氨基细胞的数量可以预测未来慢性阻塞性肺病 (COPD) 的恶化. 较高的乙素水平和较低的肺功能是COPD事件的关键风险因素.
科学领域:
- 肺部病理学 肺部病理学
- 呼吸系统医学 呼吸系统医学
- 临床研究 临床研究
背景情况:
- 慢性阻塞性肺病 (COPD) 是导致死亡的主要原因,恶化严重恶化患者的预后.
- 乙酸性气道炎症是一种已知的COPD表型,与恶化和外周血液乙酸细胞计数有关.
研究的目的:
- 在现实临床环境中调查COPD恶化的危险因素.
- 具体评估COPD恶化情况的外周血液中乙氨基细胞计数的预测值.
主要方法:
- 在2018年1月1日至2018年12月31日期间,对271名慢性慢性病患者的电子病历进行了回顾性分析.
- 在一年的随访期间收集患者人口统计数据,螺旋计数据,实验室结果和恶化事件.
- 使用单变量和多变量逻辑回归分析来确定COPD恶化风险因素.
主要成果:
- 在271名患者中,共有22名患者 (8.1%) 经历了中度至严重的恶化.
- 严重恶化的重要危险因素包括高血中乙氨基酸细胞数量 (≥350细胞/μL),低%FEV1 (<50%),白细胞数量升高 (≥9000细胞/μL) 和家庭使用氧气治疗.
- 在乙氨基酸细胞数值值和恶化风险之间观察到强烈的相关性 (r=0.89,p<0.001);与吸入治疗没有发现相关性.
结论:
- 周围血液中乙氨基酸细胞的数量在现实临床实践中作为未来COPD恶化的一个有价值的预测指标.
- 监测血中乙氨基酸水平可能有助于识别COPD患者患有恶化风险较高的患者.
相关概念视频
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
01:22Chronic Obstructive Pulmonary Disease
1.3K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.3K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
01:26COPD: Management Using Bronchodilators and Corticosteroids
255
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
255
01:20COPD: Pathogenesis and Clinical Features
368
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
368
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.9K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.9K