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白质过强度对阿波利波蛋白E对认知损伤的影响中的作用

Jacob Raber¹, Lisa C Silbert^2,3

¹Departments of Behavioral Neuroscience, Neurology, and Radiation Medicine, Division of Neuroscience, ONPRC, Oregon Health & Science University, Portland, OR, United States.

Frontiers in human neuroscience

|June 5, 2023

概括

在MRI上白质过强度 (WMH) 表明大脑血管损伤影响认知. 本综述探讨了Apolipoprotein E (apoE) 异型如何影响WMH和认知健康.

科学领域:

神经成像是一种神经成像.
神经学神经学
遗传学是一个遗传学.

背景情况:

在T2加权的MRI上,白质过强度 (WMH) 表示小血管缺血性脑血管疾病.
WMH的患病率和严重程度与衰老,心血管风险以及轻度认知障碍,血管痴呆和阿尔茨海默病等疾病的认知衰退相关.
尤其是WMH会影响执行功能,记忆和全球认知.

研究的目的:

突出WMH在认知健康和损伤中的重要性.
调查Apolipoprotein E (apoE) 和其异型在调节WMH中的作用.
提出ApoE异型对WMH的影响机制,包括对氧利平,7-胆固醇和粉样蛋白相关的血管损伤的影响.

主要方法:

审查现有的关于WMH和apoE的人类和动物研究.
对apoE异型 (E2,E3,E4) 和WMH之间的关联进行分析.
探索将apoE与白质完整性联系起来的潜在分子途径.

主要成果:

脂蛋白E (apoE) 对于保持白质完整性至关重要.
人类的apoE异型 (E2,E3,E4) 与阿尔茨海默病风险和WMH的差异性关联.
有证据表明,apoE通过脂质代谢和血管损伤途径影响WMH.

结论:

WMH是认知障碍和损伤的关键因素.
脂蛋白E (apoE) 和其异型可能在调节WMH方面发挥着重要作用.
对apoE在WMH中的作用的进一步研究可能会揭示认知障碍的新治疗点.

关键词:

亚脂蛋白 E 是一种非脂蛋白 E.认知认知认知磁共振成像 (MRI) 的使用.白质超强度是白质的超强度.白质的完整性白质的完整性

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