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两种分离的水性提取物从阿布图斯 (Arbutus) 的抗肥胖作用

Soumaya Wahabi¹, Kais Rtibi¹, Amal Atouani²

¹Laboratory of Functional Physiology and Valorization of Bio-Ressources-Higher Institute of Biotechnology of Beja, University of Jendouba, Beja, Tunisia.

Dose-response : a publication of International Hormesis Society

|June 5, 2023

概括

阿布图斯 (Arbutus unedo) (阿联) 和克拉泰格斯 (Crataegus) (CMAE) 的果实提取物显示出显著的抗肥胖作用. 这些天然化合物有效地降低了体重,并改善了肥胖大鼠的代谢健康,表明了治疗潜力.

科学领域:

药理学药理学是指药理学的学科.
营养保健品营养保健品
自然产品化学自然产品化学

背景情况:

阿布图斯 (Arbutus unedo) 和克拉泰格斯 (Crataegus monogyna) 是地中海植物,具有传统的药用.
肥胖是一个日益严重的全球健康问题,有效的治疗方法有限.

研究的目的:

为了研究Arbutus unedo (阿联) 和Crataegus monogyna (CMAE) 水性提取物对抗肥胖的潜力.
评估这些提取物对高脂肪饮食诱导的肥胖性大鼠模型中的代谢和生化参数的影响.

主要方法:

雄性Wistar大鼠被食标准饮食,高脂肪饮食 (HFD),高脂肪饮食与AUAE,高脂肪饮食与CMAE或高脂肪饮食与阿托瓦斯塔丁12周.
评估了脂质特征,肝脏和脏标记物,肥胖生物标记物,脂质过氧化,醇度,抗氧化状态和微量元素水平.

主要成果:

在HFD诱导的肥胖大鼠中,AUAE和CMAE都显著降低了体重,器官体重和脂肪组织体重.
提取物使生物化学和代谢变化正常化,减弱脂质过氧化,并增加抗氧化状态.
与HFD组相比,在接受AUAE和CMAE治疗的老鼠中观察到微量元素水平的调节.

结论:

阿布图斯 (Arbutus unedo) 和克拉泰格斯 (Crataegus monogyna) 果的水性提取物具有显著的抗肥胖特性.
阿联和CMAE证明了预防和治疗肥胖和相关代谢障碍的潜力.
这些发现支持这些植物的传统用途,并突出了它们作为营养药的价值.

关键词:

阿尔布图斯是没有的.克拉泰格斯 (Crataegus monogyna) 是一个单一的动物.有高脂肪的饮食.肝脏和脏的生物标志物肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖氧化应激是一种氧化应激.

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