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人类免疫缺陷病毒相关的非霍奇金淋巴瘤

Tesfaye Gessese¹, Fikir Asrie², Zewudu Mulatie¹

¹Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.

Blood and lymphatic cancer : targets and therapy

|June 5, 2023

概括

人类免疫缺陷病毒 (HIV) 感染者患非霍奇金淋巴瘤的风险更高. 扩散性大B细胞淋巴瘤是最常见和最严重的亚型,由免疫缺陷和病毒因素驱动.

科学领域:

在瘤学瘤学.
病毒学病毒学
免疫学免疫学免疫学

背景情况:

人类免疫缺陷病毒 (HIV) 感染与血液恶性瘤的风险增加密切相关,特别是非霍奇金淋巴瘤 (NHL).
NHL是一种获得性免疫缺陷综合征 (AIDS) 定义的癌症,占艾滋病定义恶性瘤的50%以上.
关键的致病机制包括严重的免疫缺陷,慢性抗原刺激和病毒的直接瘤发生.

研究的目的:

综合审查与艾滋病毒相关的非霍奇金淋巴瘤的流行病学,病变发生和形态学.
综合当前对HIV感染个体NHL发展的因素的理解.

主要方法:

通过使用关键词进行系统的文献搜索,例如"获得性免疫缺陷综合征"",人类免疫缺陷病毒"和"非霍奇金淋巴瘤".
相关的原创和评论文章从科学数据库中获取,包括PubMed,谷歌学者和谷歌.
搜索策略的重点是了解艾滋病毒相关NHL的流行病学,致病学和形态学方面.

主要成果:

感染艾滋病毒的人面临着持续增加患非霍奇金淋巴瘤的风险.
扩散性大B细胞淋巴瘤 (DLBCL) 是艾滋病毒相关的NHL最常见和最具攻击性的亚型.
病变发生涉及染色体异常,破坏瘤基因表达,受到病毒颗粒和细胞因子的影响.

结论:

艾滋病毒感染仍然是非霍奇金淋巴瘤的重要危险因素.
扩散性大B细胞淋巴瘤是占主导地位的亚型,其特征是复杂的病原遗传机制.
需要进一步的研究来阐明病毒颗粒和细胞因子在与艾滋病毒相关的NHL病变发生过程中的确切作用.

关键词:

伯基特淋巴瘤是一种淋巴瘤获得的免疫缺陷综合征扩散大的B细胞淋巴瘤.人类免疫缺陷病毒人类免疫缺陷病毒非霍奇金淋巴瘤的非霍奇金淋巴瘤.血细胞淋巴瘤是什么主要的中枢神经系统淋巴瘤主要输液淋巴瘤是什么

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