胃肠道恶性瘤的免疫瘤-微生物组轴
Quan Lin1, Shi-Wei Guan1, Hai-Bo Yu2
1Department of Surgery, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
World journal of gastrointestinal oncology
|June 5, 2023
概括
肠道和内微生物群通过调节瘤微环境 (TME) 来影响癌症的进展. 探索免疫瘤学-微生物组 (IOM) 轴为胃肠道恶性瘤提供了新的治疗点.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 瘤微环境 (TME) 包括瘤内微生物群,肠道细菌可能播种瘤.
- 肠道和内微生物群显著影响瘤免疫力和宿主新陈代谢.
研究的目的:
- 审查肠道和内微生物组在胃肠道癌症中的机制和进展.
- 探索与食道,胃,肝脏,结肠直肠和胰腺癌有关的免疫瘤-微生物组 (IOM) 轴.
主要方法:
- 文献综述侧重于微生物群在胃肠道恶性瘤中的作用.
- 对研究免疫瘤学-微生物组 (IOM) 轴的研究分析.
主要成果:
- 肠道和内微生物组是TME的组成部分,并影响瘤的进展.
- IOM轴突出了微生物群,宿主免疫和癌症发展之间的相互作用.
结论:
- IOM轴提供了一个新的框架,用于理解和准胃肠道癌症中的微生物群.
- 对IOM轴的进一步研究可能会为治疗这些恶性瘤提供新的治疗策略.
相关概念视频
The Tumor Microenvironment
6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K
Tumor Immunotherapy
575
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
575
Microorganisms in Medicine and Therapeutics
73
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
73
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
364
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
364
What is Monogastric Digestion?
71.7K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
71.7K
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
204
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
204


