长距离输入的全大脑映射到主要运动皮层中表达VIP的抑制神经元
Candice Lee1, Sandrine L Côté1, Nima Raman1
1Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
Frontiers in neural circuits
|June 5, 2023
概括
主要运动皮层中的血管活性肠道表达抑制性内部神经元 (VIP-IN) 优先接受与奖励相关的输入,这对早期运动学习至关重要. 这些VIP-IN集成了各种信息来调节局部电路可塑性.
科学领域:
- 神经科学是一个神经科学.
- 运动学习是指运动学习.
- 电路的可塑性 电路的可塑性
背景情况:
- 初级运动皮质 (MOp) 对于获得运动技能至关重要.
- MOp中的神经元表现出与奖励相关的活动,有助于运动学习.
- 在MOp中的血管活性肠表达抑制性内部神经元 (VIP-INs) 是早期运动学习和可塑性的关键参与者.
研究的目的:
- 为了将大脑范围内的输入映射到MOp VIP-INs.
- 了解VIP-IN如何整合感官,前运动和奖励信息.
- 将VIP-IN输入配置文件与其他抑制性内神经元 (SST-IN,PV-IN) 进行比较.
主要方法:
- 单突触性狂犬病追踪实验. 一次性狂犬病追踪实验.
- 自动细胞计数管道用于输入映射.
- 跨内部神经元亚型的神经元输入的比较分析.
主要成果:
- VIP-INs,SST-INs和PV-INs从感觉,运动和前额叶皮以及thalamic核中接收输入.
- VIP-INs显示来自轨道前皮层 (ORB) 的优先输入.
- ORB与强化学习和价值预测有关.
结论:
- VIP-IN集成了各种各样的远程输入,包括来自奖励相关地区的输入,如ORB.
- 大脑利用特定的微电路图案来调节局部电路活动和可塑性.
- 这些发现提供了关于不同内部神经元群体如何为运动学习和适应做出贡献的见解.
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