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阿司匹林作为修复膝关节关节整形手术后的血栓预防药物:回顾性分析
Eslam Abourisha1, Ananth Srinivasan1, Amit Bishnoi1
1University Hospitals of Leicester NHS Trust, UK.
Journal of orthopaedics
|June 5, 2023
概括
阿司匹林是一种安全有效的选择,用于预防修复膝关节手术后的血栓. 这项研究发现阿司匹林与其他药物一样有效,为血栓预防提供了更便宜的替代方案.
科学领域:
- 整形外科手术 整形外科手术
- 药理学 药理学是指药理学的学科.
- 血管医学 血管医学
背景情况:
- 修复膝关节关节整形手术存在严重并发症的风险,例如静脉血栓栓塞.
- 在修复膝关节关节整形术后的最佳血栓预防仍然是一个不确定的领域.
研究的目的:
- 评估阿司匹林作为血栓预防剂在接受修复膝关节关节整形手术的患者中的疗效和安全性.
- 为了比较阿司匹林与其他预防药物的有效性.
主要方法:
- 490名接受修复膝关节关节整形手术 (2013-2020) 的患者的回顾性审查.
- 在手术后90天内对症状性血栓栓塞事件的分析.
- 评估二次结果,包括出血,感染,再接收和死亡率.
主要成果:
- 374名患者每天服用阿司匹林 (150毫克,持续28天),75名患者服用达尔特帕林.
- 整体静脉血栓栓塞率为0.6% (3/490);症状性DVT的发生率为0.8% (3/374).
- 阿司匹林与其他药物之间的VTE发病率没有显著差异;没有观察到重大出血事件.
结论:
- 阿司匹林的疗效与其他药物相比,在延长的非医院血栓塞栓预防中具有可比的效果.
- 阿司匹林是一种安全,有效和经济高效的替代血栓预防药物.
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