在3P医学框架下,多方面的CRISPR/Cas技术创新方面
Vincent Lučanský1, Veronika Holubeková1, Zuzana Kolková1
1Martin, Slovakia Jessenius Faculty of Medicine in Martin (JFMED CU), Biomedical Center, Comenius University in Bratislava.
The EPMA journal
|June 5, 2023
概括
预测,预防和个性化医学 (PPPM / 3PM) 正在推进医疗保健. 基因编辑CRISPR显示出疾病预防和治疗的前景,但面临着广泛临床使用的技术和伦理障碍.
科学领域:
- 基因组学和个性化医学
- 生物技术和基因编辑
背景情况:
- 欧洲预测,预防和个性化医学协会 (EPMA) 倡导从反应性到主动性医疗保健的转变.
- 在生物医学研究和临床应用中,CRISPR/Cas基因编辑技术具有显著的潜力.
- 预测,预防和个性化医学 (PPPM/3PM) 旨在预防疾病过渡并改善患者的生活质量.
研究的目的:
- 突出CRISPR/Cas基因编辑中的技术创新,用于PPPM/3PM.
- 讨论CRISPR/Cas在医疗保健中的当前成果,技术挑战和伦理考虑.
- 在PPPM/3PM框架内为基因编辑提供临床相关的前景.
主要方法:
- 对CRISPR/Cas基因编辑技术进步的审查.
- 分析目前在诊断和实验性治疗中的应用 (例如,SARS-CoV-2).
- 讨论阻碍临床实施的技术和伦理挑战.
主要成果:
- 克里斯普尔/卡斯技术在生物/医学研究中具有广泛的价值.
- 确定了疾病预防和治疗的初级和二级医疗保健中的潜在应用.
- 对于规模化的临床使用,仍然存在重大的技术和伦理挑战.
结论:
- 克里斯普尔/卡斯基因编辑对预测,预防和个性化医学 (PPPM/3PM) 具有变革潜力.
- 解决技术障碍和伦理考虑对于临床翻译至关重要.
- 需要进一步的研究和开发,才能实现基因编辑在医疗保健中的全部好处.
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