与口服消血剂使用相关的急性缺血性结肠炎:系统性审查
Muhammad Hassan Naeem Goraya1, Faisal Inayat1, Sobaan Taj2
1Department of Internal Medicine, Allama Iqbal Medical College, Lahore, Pakistan.
Journal of clinical and translational research
|June 5, 2023
概括
口服消血剂,如伪乙和烯可以引起急性缺血性结肠炎 (IC),这是一个罕见但严重的疾病. 早期诊断和避免这些非处方药非常重要,尤其对女性来说.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 内部医学 内部医学
背景情况:
- 急性缺血性结肠炎 (IC) 曾经与口服消血剂使用有关.
- 支持这种关联的临床证据有限.
- 无处方药 (OTC) 降血剂,如伪和烯,广泛可用.
研究的目的:
- 为了评估急性IC的发病率和临床结果,在OTC使用伪和烯酸后.
- 评估临床表现,诊断发现和与口服脱血剂相关的IC病例的治疗.
主要方法:
- 进行了对多个数据库 (MEDLINE,Google Scholar,Scopus,Embase) 的系统审查.
- 收录标准集中在英语文章中,详细介绍 pseudoephedrine或phenylephrine 的次要急性IC.
- 从18个符合条件的病例报告 (证据水平:IV) 进行了数据提取.
主要成果:
- 鉴定了18例与口服脱血剂相关的急性IC病例报告.
- 常见的症状包括腹痛 (88.9%) 和血 (83.3%).
- 高血压和吸烟是常见的并发病;白细胞病是常见的 (72.2%).
结论:
- 与口服脱血剂相关的急性IC是一种罕见但显著的临床事件.
- 通过成像和结肠镜活检支持的临床怀疑对于早期诊断至关重要.
- 应询问患者在不明原因的IC病例中使用OTC降血剂,并且应避免在轻度症状下使用这些药物,特别是在女性中.
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