身体组成和肝癌风险:基于人群的前性队列研究性别差异
Sainan Pi1, Anran Liu2, Beibei Zhu3
1Department of Infectious Diseases, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.
Frontiers in nutrition
|June 5, 2023
概括
肥胖会增加肝癌的风险,身体成分在性别方面发挥着特定作用. 身体脂肪较高的男性面临更高的风险,而女性在某些身体成分指标的高和低水平上都有更高的风险.
科学领域:
- 在瘤学瘤学.
- 代谢健康 代谢健康
- 流行病学 流行病学
背景情况:
- 肥胖是许多癌症的重要危险因素,包括肝癌.
- 能量恒温和身体组成的性别差异可能会影响癌症发病率.
- 关于身体成分与肝癌风险之间的性别特异性联系的数据有限.
研究的目的:
- 检查身体组成和肝癌风险之间的线性和非线性关系.
- 对于男性和女性来说,分别调查这些关联.
主要方法:
- 来自英国生物银行的475,659名无癌症参与者的前性分析.
- 考克斯的比例危险模型被用于评估风险,并对混因素进行调整.
- 限制的立方线分析了非线性关联.
主要成果:
- 在男性中,较高的体脂百分比与肝癌风险增加相关 (HR=1.89).
- 增加全身脂肪量,手臂脂肪量和干脂肪量与男性肝癌风险更高有关.
- 妇女表现出U形的关联,高和低水平的全身无脂肪质量 (特别是手臂和干部) 与肝癌风险增加有关.
结论:
- 身体成分和肝癌风险之间存在明显的性别相关性.
- 这些发现支持针对肝癌预防的量身定制体重管理策略.
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