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Updated: Jul 27, 2025

Analysis of Fatty Acid Content and Composition in Microalgae

Analysis of Fatty Acid Content and Composition in Microalgae

Published on: October 1, 2013

马来西亚棕色宏观藻类

Kogilavani Subermaniam^1,2, Sze Yuen Lew¹, Yoon Yen Yow³

¹Department of Anatomy, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.

Iranian journal of basic medical sciences

|June 5, 2023

概括

马来西亚帕迪纳南方提取物 (PAEE) 通过抑制活性氧物种 (ROS) 和促炎细胞因子,降低了微质细胞中的神经炎症. 这表明P. australis是神经退行性疾病的潜在治疗方法.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
海洋生物学海洋生物学

背景情况:

神经炎症和微质激活是中枢神经系统疾病的关键病理特征.
过多的活性氧物种 (ROS) 和促炎性细胞因子会在慢性微质激活过程中加剧神经元损伤.
棕色藻 (Padina australis) 具有抗神经炎症的特性,但其机制尚不清楚.

研究的目的:

调查马来西亚帕迪纳南方乙醇提取物 (PAEE) 在减轻脂多糖 (LPS) 诱导的神经炎症方面的潜力.
阐明P. australis在BV2微质细胞中的抗神经炎症作用的机制.

主要方法:

用脂聚糖 (LPS) 刺激了BV2微质细胞.
评估了不同度的P. australis乙醇提取物 (PAEE) 对细胞活力,氧化 (NO),前列腺素E2 (PGE2),细胞内ROS和炎症标志物 (iNOS,COX-2,TNF-α,IL-6) 的影响.
液态染色体质谱法 (LC-MS) 用于识别PAEE中的化合物.

主要成果:

在LPS刺激下,增加了NO,PGE2,细胞内ROS,iNOS,COX-2,TNF-α和IL-6水平,同时降低了细胞活力.
根据剂量,PAEE治疗 (0.5-2.0 mg/ml) 逆转了这些LPS诱导的效应.
在LC-MS分析中,在PAEE中发现了甲基α-eleostearate,乙基α-eleostearate,尼亚辛胺,胺和酸.

结论:

在BV2微质细胞中,PAEE有效抑制LPS诱导的神经炎症.
抗神经炎症作用归因于细胞内ROS和促炎介质的减少.
在神经炎症和神经退行性疾病中,Padina australis显示出治疗潜力.

关键词:

在BV2微质细胞中.棕色藻类是一种色藻类.细胞因子 (cytokines) 是一种细胞因子.主要的化合物主要是化合物.神经炎症是一种神经炎症.氧化作用的损伤.

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