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折叠驱动器皮质厚度的变化

Maria A Holland1, Silvia Budday2, Gang Li3

  • 1Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.

The European physical journal. Special topics
|June 5, 2023
PubMed
概括

大脑折叠在物理上驱动皮质厚度的变化,在发育过程中会出现状组织的加厚和状组织的稀薄. 这些模式自然出现,为神经系统疾病提供了洞察力.

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科学领域:

  • 神经科学是一个神经科学.
  • 发展生物学 发展生物学
  • 生物物理学的生物物理.

背景情况:

  • 皮层厚度是神经系统疾病的关键生物标志物.
  • 人类大脑皮层厚度的变化是显著的,但它们的发育起源不清楚.
  • 以前的模型表明,物理力驱动皮质折叠,导致异质性.

研究的目的:

  • 为了研究皮层厚度随时间变化的演变.
  • 要确定皮层折叠期间的物理力是否解释厚度异质性.
  • 为了将遗传,几何和物理因素与大脑发育联系起来.

主要方法:

  • 在双层系统模型上进行扩展,以探索厚度演变.
  • 分析了健康成年人 (n=573) 和婴儿 (n=73) 的磁共振图像.
  • 观察到类似模式形成的皮质器官发展.

主要成果:

  • 皮层折叠自然会导致更厚的gyri和更薄的sulci,独立于区域信息.
  • 观察到的厚度变化与人类大脑在广泛的年龄范围内的模式保持一致.
  • 皮质器官在生长过程中回顾了这些厚度变化.

结论:

  • 在皮层折叠过程中的物理力是产生皮层厚度变化的重要因素.
  • 这些发现表明大脑发育过程中遗传,几何和物理过程之间的相互作用.
  • 了解这些变异有助于诊断和治疗神经系统疾病.