水性乙醇提取物的抗作用
Edwige T Delma1,2, Moussa Ouédraogo1,2, Aimé S Ouédraogo2,3
1Laboratoire de Développement du Médicament, Ecole Doctorale Sciences et Santé (ED2S), Université Joseph KI-ZERBO, Ouagadougou, Burkina Faso.
Journal of experimental pharmacology
|June 5, 2023
概括
伪树和西米尼亚美利卡提取物在胃潰瘍治疗中表现有前途. 在临床前模型中,Ximenia americana提取物表现出优越的胃细胞保护和愈能力.
科学领域:
- 药理学 药理学是指药理学的学科.
- 民族植物学 民族植物学
- 植物化学 植物化学
背景情况:
- 布基纳法索的传统医生使用Pseudocedrela kotschyi和Ximenia americana来治疗胃潰瘍.
- 科学验证这些民族医学主张对于理解它们的治疗潜力至关重要.
研究的目的:
- 提供药理学证据证明Pseudocedrela kotschyi和Ximenia americana在预防和治疗胃潰瘍方面的有效性.
- 在已建立的模型中研究植物提取物的细胞保护和治疗作用.
主要方法:
- 从Pseudocedrela kotschyi (树干皮) 和Ximenia americana (根皮) 制备干燥的提取物.
- 在动物中使用盐酸和低温压力模型诱导胃潰瘍.
- 评估不同剂量的细胞保护作用和21天的治愈作用.
- 评估抗氧化活性 (DPPH基因抑制,铁降低抗氧化能力) 和总含量.
主要成果:
- 伪草和西米尼亚美利卡提取物都显著降低了的发作指数,分别降低了83%和65%.
- 美国西门子提取物在10毫克/千克的剂量实现了完全的愈,超过了组合提取物.
- 植物提取物表现出强烈的抗氧化活性,IC50值低于5μg/mL,总含量高.
结论:
- 与Pseudocedrela kotschyi及其组合相比,Ximenia americana提取物显示出优越的胃细胞保护和愈特性.
- 观察到的药理效应得到了提取物显著的抗氧化剂和高含量的支持.
- 需要进一步的研究来阐明这些治疗效益的确切作用机制.
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