在患有牛皮和亚托皮皮炎的患者中,生物诱导的免疫表型交叉切换
Yanyan Li1,2, Hong Liu1,2, Furen Zhang1,2
1From the Shandong Provincial Hospital for Skin Diseases and Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong, China.
Indian journal of dermatology
|June 5, 2023
概括
对湿疹和牛皮的生物疗法可以矛盾地导致相反的情况. 本综述检查了在湿疹中使用dupilumab引起的牛皮形喷发,以及在牛皮中使用生物药物的湿疹反应.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 针对细胞因子信号的生物制剂是皮肤病学的支柱.
- 越来越多地认识到悖论性反应,即治疗诱导或恶化了其他条件.
- 治疗湿疹的杜皮卢马布可以引起牛皮形爆发 (P-PRs);治疗牛皮的生物药物可以引起湿疹爆发 (E-PRs).
研究的目的:
- 系统地审查和总结P-PRs在亚型皮肤炎 (AD) 和E-PRs在牛皮的病例特征.
- 探索与生物制剂和患者遗传学相关的潜在机制和遗传联系.
- 了解牛皮和由生物制剂诱导的湿疹性皮肤炎之间的表型过渡.
主要方法:
- 对AD患者治疗dupilumab的P-PRs的文献进行系统审查.
- 对用生物药物治疗的牛皮患者的E-PR进行文献的系统审查.
- 分析病例特征,潜伏期和患者病史.
主要成果:
- 在AD中确定了42例杜皮卢马布诱导的P-PRs,平均发病时间为22.65周.
- 在牛皮中审查了51例生物诱导的E-PR,平均发病时间为24.47周;IL-17A抑制剂涉及72.55%.
- 在48.98%的E-PR病例中报告了亚托皮病史,这表明潜在的危险因素.
结论:
- 生物疗法可以诱导矛盾的牛皮形或湿疹喷发.
- 亚托皮可能会增加这些矛盾反应的风险.
- 需要进一步的研究来阐明患病率和病理生理机制.
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