患有斑块性牛皮的患者的牙下微生物群和牙周临床状态:一个横截面研究
Grissel Orozco-Molina1, Miguel Casillas-Santana2, Abigailt Flores-Ledesma3
1From the Universidad del Valle de Guerrero, Chilpancingo de los Bravo, Guerrero México. 39047, México.
Indian journal of dermatology
|June 5, 2023
概括
斑块性牛皮 (PP) 和牙周炎共享炎症途径. 这项研究发现,特定的口腔细菌,特别是Actinomyces,与牛皮的严重程度有关,可能会增加牙周炎的风险.
科学领域:
- 口腔微生物学 口腔微生物学
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
背景情况:
- 斑块性牛皮 (PP) 和牙周炎是具有既定的双向联系的慢性炎症状况.
- 这两种疾病都有类似的免疫调节途径,细胞因子概况和微生物失调症的证据.
- 牙周囊中的口腔微生物群的组成可能会影响PP的发展.
研究的目的:
- 描述墨西哥斑块牛皮 (PP) 患者的下微生物群,并评估他们的牙周状况.
- 为了研究牛皮病严重程度,牙周健康和特定细菌物种之间的关联.
- 探索细胞因子IL-2和IL-6在PP和牙周炎中的作用.
主要方法:
- 临床检查和将患者分为牙周健康 (PH) 和牙周炎 (PD) 组,按PP状态分层 (PP与非PP).
- 牛皮的严重程度使用牛皮严重程度指数 (PASI) 进行评估.
- 下细菌物种 (40种) 量化使用棋盘DNA-DNA杂交;IL-2和IL-6通过ELISA测量.
主要成果:
- 与PP和牙周炎 (PD-PP) 患者相比,PP和牙周健康 (PH-PP) 患者的牙周参数 (斑块,红色,探针深度,附着损失) 显著差.
- 与非PP患者患有牙周炎相比,PD-PP组的Actinomyces georgiae,Actinomyces israelii和Actinomyces naeslundii的数量更高.
- 增加的Actinomyces计数与更高的PASI得分相关,这表明牛皮的严重程度和特定的细菌失生症之间存在联系.
结论:
- 与没有PP的个体相比,具有PP的个体具有明显的下菌群特征.
- 牛皮的严重程度,特别是PASI>5,与牙周异位症有关,其特点是Actinomyces占主导地位,无论牙周状况如何.
- 牛皮的严重程度可能会破坏下微生物群,可能增加患牙周炎的风险.
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