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延迟和有限的JAKinib托法西提尼布的管理减轻慢性DSS诱导的大肠炎

Rishav Seal1, Lara S U Schwab1, Cristina M Chiarolla1

  • 1Institute of Pathology, Julius-Maximilians-University Würzburg, Würzburg, Germany.

Frontiers in immunology
|June 5, 2023
PubMed
概括

在大肠炎模型中,两轮托法西提尼布治疗有效控制了炎症性肠病. 这种间歇性治疗减少了促炎性细胞因子,促进了愈合,超过了更长的治疗时间.

关键词:
在AOM/DSS中使用.这是一种JAK抑制剂.抗炎性细胞因子是一种抗炎性细胞因子.慢性IBD模型模型效应因子Treg (eTreg) 的使用.有助于炎症的细胞因子.托法西提尼布 (tofacitinib) 是一种治疗方案 治疗方案

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