多个促炎性刺激的效应
Julia Heiter1,2, Matthew W Kemp3, Owen B Spiller4
1Division of Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, Netherlands.
Frontiers in immunology
|June 5, 2023
概括
来自Ureaplasma parvum或脂多糖暴露的胆膜炎会损害胎儿肠道的发育. 炎症和神经变化随着更长时间或重复暴露而恶化,可能会影响婴儿的健康.
科学领域:
- 产周医学 产周医学
- 发育生物学是发展生物学.
- 胃肠病学 胃肠病学
背景情况:
- 胆 ?? 膜炎是早产的一个常见并发症.
- 它与新生儿肠道炎症和死性肠球炎的风险增加有关.
- 肠道炎症可以扰乱肠道神经系统的发展.
研究的目的:
- 调查由Ureaplasma parvum和/或脂多糖 (LPS) 诱导的胆 ?? 膜炎对胎儿乳腺炎和肠道神经系统 (ENS) 发育的影响.
- 为了确定反复或慢性暴露于炎症刺激是否会影响这些结果.
- 为了在妊娠年龄相当于60个月的60%的早期生命炎症的模型.
主要方法:
- 绵羊胎儿通过在分娩前不同时间内静脉内注射暴露于慢性Ureaplasma parvum和/或LPS.
- 通过量化炎症细胞标志物 (CD3,髓氧化酶) 来评估肠道炎症.
- 通过评估神经元核和质细胞 (星状细胞) 群体来评估ENS结构变化.
主要成果:
- 暴露于LPS会增加炎症细胞的透.
- 重复的LPS或联合的Ureaplasma parvum/LPS暴露显著增加了肠道炎症.
- 在所有干预组中,神经元细胞核都下降了,最显著的是重复性LPS.
- 在LPS暴露 (2天前) 或慢性Ureaplasma parvum暴露后,星状细胞类质细胞增加.
结论:
- 在胎儿发育过程中暴露于胆膜炎会导致显著的肠道炎症和内脏神经系统的结构变化.
- 这些炎症和结构变化的严重程度取决于剂量和持续时间.
- 这些发现凸显了婴儿暴露于产前炎症的潜在长期功能后果.
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