炎症性肠病与骨矿物质密度和骨质疏松症的遗传预测因果关系:来自双样本孟德尔随机化的证据
Dengyong Xu1, Yao Chen2, Xing Gao3
1Department of Colorectal Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Frontiers in immunology
|June 5, 2023
概括
炎症性肠病 (IBD) 与较低的骨矿物密度 (BMD) 和骨质疏松症风险增加有关. 这项研究证实了因果关系,突出了IBD患者的BMD监测的需要.
科学领域:
- 遗传学 是一个遗传学.
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
背景情况:
- 炎症性肠病 (IBD),包括性结肠炎 (UC) 和克罗恩病 (CD),与骨矿物质密度 (BMD) 降低和骨质疏松症 (OS) 患病率提高有关.
- 现有的回顾性研究表明存在联系,但需要进一步调查的因果关系.
研究的目的:
- 调查IBD和骨代谢障碍之间的因果关系,特别是全身低BMD和OS.
- 用遗传数据分析欧洲和东亚人口中的这些关系.
主要方法:
- 使用公开可用的全基因组关联研究 (GWAS) 总结统计数据进行了两样本的门德尔随机化分析 (TSMR).
- 对于IBD,UC,CD,全身BMD和OS的仪器变量 (SNPs) 通过严格的质量控制来选择.
- 逆方差加权 (IVW) 是主要的分析方法,并补充了异质性,多变性和灵敏度分析.
主要成果:
- 在欧洲人中,UC和整体IBD显示出与下部全身BMD有显著的遗传关联. 所有IBD亚型 (UC,CD,整体IBD) 都是具有病理性骨折的OS显著遗传风险因素.
- 在东亚人中,只有CD与OS有显著的因果关系.
- 在不同种族群体中观察到IBD,全身BMD和OS之间的遗传关联.
结论:
- 这项门德尔随机化研究提供了基因证据,支持IBD和骨代谢障碍之间的关联,包括减少BMD和增加OS风险.
- 这些发现强调了定期对IBD诊断的患者进行骨损伤监测的重要性,以减轻骨并发症.
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