ACE2对COVID-19的保护性潜在作用
Fereshteh Golab1, Gelareh Vahabzadeh2, Leila SadeghRoudbari1
1Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Advances in virology
|June 5, 2023
概括
本综述探讨了血管酶转化酶2 (ACE2) 如何作为SARS-CoV-2感染的关键受体. 了解ACE2在COVID-19病变发生过程中的作用可能会导致新的治疗策略.
科学领域:
- 病毒学 病毒学
- 心血管研究研究心血管研究
- 传染性疾病 传染性疾病
背景情况:
- 冠状病毒疾病2019 (COVID-19) 流行病需要紧急的治疗开发.
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 使用血管素转化酶2 (ACE2) 作为细胞进入和感染的关键受体.
- 由SARS-CoV-2尖端蛋白降低ACE2的调节会触发有害的 ангиотензинII (Ang II) / ангиотензин1型受体轴过度激活.
研究的目的:
- 审查ACE2在SARS-CoV-2感染中的关键作用.
- 探索ACE2对病毒感染的潜在保护机制.
- 为开发新的COVID-19预防和控制策略提供见解.
主要方法:
- 关于ACE2,SARS-CoV-2和COVID-19病变的现有研究的文献综述.
- 分析SARS-CoV-2尖端蛋白与ACE2之间的分子相互作用.
- 检查COVID-19中ACE2下调的生理后果.
主要成果:
- 在SARS-CoV-2介导的细胞融合和感染中,ACE2是必不可少的.
- 降低ACE2的调节导致有害的Ang II/AT1R轴过度激活,导致COVID-19患者的器官功能障碍.
- ACE2的广泛分布有助于COVID-19中观察到的各种症状和并发症.
结论:
- ACE2作为病毒受体和氨酸系统的关键调节器具有双重作用.
- 准ACE2或其相关途径可能提供针对SARS-CoV-2感染的保护策略.
- 进一步研究ACE2的功能对于开发有效的COVID-19治疗方法和控制措施至关重要.
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