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Updated: Jul 16, 2026

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
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High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels

Published on: January 27, 2013

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人类平衡核酸转运体1 (hENT1) 的组装特征通过以抑制剂探针为基础的dSTORM成像.

Binglin Sui1, Junling Chen1, Dian Ge1

  • 1Improve-WUST Joint Laboratory of Advanced Technology for Point-of-Care Testing and Precision Medicine, School of Chemistry & Chemical Engineering, Wuhan University of Science and Technology, 947 Heping Street, Wuhan, Hubei 430081, China.

Analytical chemistry
|June 5, 2023
PubMed
概括

研究人员开发了一种新的光探针和显微镜技术,以在单个分子水平上可视化人类平衡核酸载体1 (hENT1). 这揭示了hENT1在细胞膜上的明显的组装模式,为核酸代谢和药物疗效提供了洞察力.

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相关概念视频

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)01:20

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)

When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...