与年龄相关的血液体积变化 手指和耳朵的脉冲波
IEEE journal of biomedical and health informatics
|June 5, 2023
概括
新的光多聚光显微镜 (PPG) 功能与时间年龄有很强的相关性,为血管衰老提供了潜在的生物标志物. 这些与年龄相关的PPG信号变化反映了动脉硬度的进展,类似于脉冲波速度 (PWV).
科学领域:
- 心血管生理学心血管生理学
- 生物医学工程 生物医学工程
- 老年学是一门学科.
背景情况:
- 衰老导致血管弹性降低,影响脉冲波特征.
- 摄影透视图 (PPG) 提供了一种非侵入性方法来评估血管健康.
- 现有的PPG特征与年龄有适度的相关性.
研究的目的:
- 为了识别基于PPG的新型脉冲波特征,对年龄敏感.
- 为了检查这些特征如何随着健康个体年龄的增长而改变.
- 将拟议的PPG特征的年龄敏感性与现有方法和黄金标准进行比较.
主要方法:
- 从手指PPG波形及其衍生物中提取了五个新的特征.
- 在100名健康受试者 (20-71岁) 中,进行了PPG特征和年龄之间的相关性分析.
- 零碎回归评估了不同生命阶段与年龄相关的变化率,与脉冲波速度 (PWV) 进行比较.
主要成果:
- 提出的PPG特征显示出与年龄有很强的显著相关性 (r=0.76-0.77,p<0.01),超过了之前的发现.
- 与年龄相关的PPG特征的变化在40岁及以上的个体中显著加快.
- PPG特征的变化速度与PWV测量的与年龄相关的动脉硬性进展密切相似.
结论:
- 新的PPG特征对健康成年人的时间年龄高度敏感.
- 这些特征表现出与年龄相关的趋势,与动脉硬的黄金标准PWV相似.
- 拟议的PPG生物标志物对评估血管衰老和心血管疾病风险充满希望.
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